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Amitifadine hydrochloride

Name: Amitifadine hydrochloride
Brand: TargetMol
SKU: T2092
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2092Cas No. 410074-74-7

Alias EB-1010 hydrochloride, DOV-21947 hydrochloride

Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Amitifadine hydrochloride

🥰Excellent

Catalog No. T2092Alias EB-1010 hydrochloride, DOV-21947 hydrochlorideCas No. 410074-74-7

Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$239	In Stock
10 mg	$396	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

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Product Introduction

Bioactivity

Description	Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Targets&IC50	5-HT (HEK293 cells):12 nM, Norepinephrine (HEK293 cells):23 nM, Dopamine (HEK293 cells):96 nM
Synonyms	EB-1010 hydrochloride, DOV-21947 hydrochloride

Chemical Properties

Molecular Weight	264.58
Formula	C₁₁H₁₂Cl₃N
Cas No.	410074-74-7
Smiles	Cl.Clc1ccc(cc1Cl)[C@@]12C[C@@H]1CNC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7796 mL	18.8979 mL	37.7958 mL	188.9788 mL
5 mM	0.7559 mL	3.7796 mL	7.5592 mL	37.7958 mL
10 mM	0.3780 mL	1.8898 mL	3.7796 mL	18.8979 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc