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CD73-IN-3

Name: CD73-IN-3
Brand: TargetMol
SKU: T8875
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8875Cas No. 2375815-63-5

Alias LY-3475070, EX-A4254

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.

CD73-IN-3

🥰Excellent

Purity: 99.76%

Catalog No. T8875Alias LY-3475070, EX-A4254Cas No. 2375815-63-5

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$148	In Stock
10 mg	$238	In Stock
25 mg	$398	In Stock
50 mg	$567	In Stock
100 mg	$768	In Stock
200 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Batch Information

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Purity:99.76%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.
Targets&IC50	CD73:28 nM
Synonyms	LY-3475070, EX-A4254

Chemical Properties

Molecular Weight	286.33
Formula	C₁₅H₁₈N₄O₂
Cas No.	2375815-63-5
Smiles	[H][C@@]1(C[C@@H]1C(C)C)c1cc(nnc1C)-c1c[nH]c(=O)[nH]c1=O
Relative Density.	1.245 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (78.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4925 mL	17.4624 mL	34.9247 mL	174.6237 mL
5 mM	0.6985 mL	3.4925 mL	6.9849 mL	34.9247 mL
10 mM	0.3492 mL	1.7462 mL	3.4925 mL	17.4624 mL
20 mM	0.1746 mL	0.8731 mL	1.7462 mL	8.7312 mL
50 mM	0.0698 mL	0.3492 mL	0.6985 mL	3.4925 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc