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Hexamethylene bisacetamide

Name: Hexamethylene bisacetamide
Brand: TargetMol
SKU: T7863
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7863Cas No. 3073-59-4

Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.

Hexamethylene bisacetamide

🥰Excellent

Purity: 99.94%

Catalog No. T7863Cas No. 3073-59-4

Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.

Pack Size	Price	Availability
50 mg	$40	In Stock
100 mg	$55	In Stock
500 mg	$129	In Stock
1 g	$193	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Batch Information

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Purity:99.94%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
In vitro	As expected of a BET inhibitor, HMBA displaced BET proteins from chromatin, caused massive transcriptional changes, and triggered cell-cycle arrest and apoptosis in Myc-induced B-cell lymphoma cells.?Furthermore, HMBA exerted anticancer effects in vivo in mouse models of Myc-driven B-cell lymphoma[1].

Chemical Properties

Molecular Weight	200.28
Formula	C₁₀H₂₀N₂O₂
Cas No.	3073-59-4
Smiles	CC(=O)NCCCCCCNC(C)=O
Relative Density.	0.974 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (124.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9930 mL	24.9650 mL	49.9301 mL	249.6505 mL
5 mM	0.9986 mL	4.9930 mL	9.9860 mL	49.9301 mL
10 mM	0.4993 mL	2.4965 mL	4.9930 mL	24.9650 mL
20 mM	0.2497 mL	1.2483 mL	2.4965 mL	12.4825 mL
50 mM	0.0999 mL	0.4993 mL	0.9986 mL	4.9930 mL
100 mM	0.0499 mL	0.2497 mL	0.4993 mL	2.4965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc