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Cefotetan

Name: Cefotetan
Brand: TargetMol
SKU: T7043
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7043Cas No. 69712-56-7

Alias Apacef

Cefotetan (Apacef) Sodium (ICI-156834, YM-09330) is a second-generation cephalosporin, cephamycin antibiotic that is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.

Cefotetan

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Purity: 99.38%

Catalog No. T7043Alias ApacefCas No. 69712-56-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$93	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$185	In Stock	In Stock
200 mg	$278	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.38%

Appearance:solid

Color:White

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COA

Product Introduction

Cefotetan AI Summary

Cefotetan exhibits a wide range of biological activities, including potent antibacterial and antiviral properties. Its antimicrobial effects include high potency against aerobic bacteria such as Escherichia coli and Klebsiella pneumoniae with minimum inhibitory concentrations (MIC) as low as 0.031 ug/mL. It is effective against anaerobic bacteria like Clostridium perfringens and Bacteroides thetaiotaomicron with MIC values ranging from 1.0 to 16.0 ug/mL, though it shows limited activity against others such as Bacteroides melaninogenicus with MIC values greater than 128.0 ug/mL. Additionally, Cefotetan has shown efficacy in inhibiting resistant strains of Escherichia coli and Shigella sonnei expressing beta-lactamase enzymes, with MIC values as low as 0.5 ug/mL. In pharmacokinetic studies, Cefotetan demonstrates species-specific distribution and clearance rates. In humans, it has a low volume of distribution (0.13 L.kg-1) and a short half-life of 4.5 hours, indicating moderate bioavailability and fast elimination. In animal models such as rats, dogs, and monkeys, the compound shows higher distribution volumes and faster clearance rates, suggesting variable bioavailability across species. Cefotetan also exhibits moderate hepatotoxicity with elevated levels of liver enzymes (ALT, AST, and alkaline phosphatase), albeit without severe liver damage. It also shows inhibitory activity on human bile salt export pump (BSEP) and multidrug resistance-associated proteins (MRP) with relatively low potency (IC50 values greater than 135,000 nM). In antiviral studies, Cefotetan demonstrates activity against SARS-CoV-2 by inhibiting the 3CL-Pro protease and decreasing viral-induced cytotoxicity in cell lines. However, its potency appears to be relatively low, with an IC50 value greater than 20,000 nM. Overall, Cefotetan is a multifaceted compound with notable antibacterial and antiviral activities, moderate hepatotoxicity, and specific pharmacokinetic profiles across different species..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefotetan (Apacef) Sodium (ICI-156834, YM-09330) is a second-generation cephalosporin, cephamycin antibiotic that is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Synonyms	Apacef

Chemical Properties

Molecular Weight	575.62
Formula	C₁₇H₁₇N₇O₈S₄
Cas No.	69712-56-7
Smiles	CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O
Relative Density.	2.07 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (434.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7373 mL	8.6863 mL	17.3726 mL	86.8629 mL
5 mM	0.3475 mL	1.7373 mL	3.4745 mL	17.3726 mL
10 mM	0.1737 mL	0.8686 mL	1.7373 mL	8.6863 mL
20 mM	0.0869 mL	0.4343 mL	0.8686 mL	4.3431 mL
50 mM	0.0347 mL	0.1737 mL	0.3475 mL	1.7373 mL
100 mM	0.0174 mL	0.0869 mL	0.1737 mL	0.8686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc