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DMG-PEG 2000

Name: DMG-PEG 2000
Brand: TargetMol
SKU: T9098
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: DMG-PEG2000) Copy Product Info

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Synonyms: DMG-PEG2000

Catalog No. T9098 Copy Product Info

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DMG-PEG 2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for the in vivo delivery of plasmid DNA via oral administration, enhancing the mucosal permeability and delivery efficiency of the nanoparticles. DMG-PEG 2000 can be used for the preparation of liposomes for siRNA transfection, improving transfection efficiency.

Cas No. 160743-62-4

Pack Size	Price	USA Stock	Global Stock
25 mg	$30	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$64	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	DMG-PEG 2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for the in vivo delivery of plasmid DNA via oral administration, enhancing the mucosal permeability and delivery efficiency of the nanoparticles. DMG-PEG 2000 can be used for the preparation of liposomes for siRNA transfection, improving transfection efficiency.
In vivo	METHODS: To study the permeability of NP-3, a single dose of NP-3 (150 μg DNA per mouse) was administered orally to mice. RESULTS: The NP-3 group maintained high luciferase expression in the liver, lung, and intestinal regions within 12 to 24 hours after administration. In addition, NP-3 showed a 1.5-fold higher signal intensity than the NP-1 or NP-2 groups within 12 to 24 hours after oral administration. [1]
Synonyms	DMG-PEG2000

Chemical Properties

Molecular Weight	2526
Formula	(C₂H₄O)nC₃₂H₆₂O₅
Cas No.	160743-62-4
Smiles	N.CCCCCCCCCCCCCC(=O)OCC(COCCOC)OC(=O)CCCCCCCCCCCCC
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (39.59 mM), Sonication is recommended.

DMSO: 60 mg/mL (23.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (0.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	0.3959 mL	1.9794 mL	3.9588 mL	19.7941 mL
5 mM	0.0792 mL	0.3959 mL	0.7918 mL	3.9588 mL
10 mM	0.0396 mL	0.1979 mL	0.3959 mL	1.9794 mL
20 mM	0.0198 mL	0.0990 mL	0.1979 mL	0.9897 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc