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γ-Fibrinogen 377-395

Name: γ-Fibrinogen 377-395
Brand: TargetMol
SKU: T80683
Rating: 4.5 (1 reviews)

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Catalog No. T80683Cas No. 957792-67-5

γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1].

γ-Fibrinogen 377-395

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Catalog No. T80683Cas No. 957792-67-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1].
In vitro	The compound γ-Fibrinogen377-395 at a concentration of 200 μM inhibits the binding of fibrinogen to Mac-1, thereby reducing the adhesion of Mac-1 overexpressing cells to immobilized fibrinogen. Additionally, γ-Fibrinogen377-395 suppresses the activation of microglia [1].
In vivo	γ-Fibrinogen377-395 (30 μg/mouse; intranasal administration; once daily for 40 days) improved motor function in mice without affecting peripheral immune responses or altering coagulation properties. Additionally, mice immunized with γ377-395 peptide before EAE induction showed enhanced motor strength and coordination compared to the control group [1].

Chemical Properties

Molecular Weight	2229.66
Formula	C₁₀₀H₁₆₅N₂₅O₂₈S₂
Cas No.	957792-67-5
Smiles	C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CO)=O)CCSC)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CCSC)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)(=O)N2[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)=O)CCC2
Sequence	Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
Sequence Short	YSMKETTMKIIPFNRLSIG

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc