Tanerasertib

Name: Tanerasertib
Brand: TargetMol
SKU: T211766
Rating: 4.5 (1 reviews)

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Tanerasertib is an AKT1 inhibitor that can specifically target the AKT1 E17K mutant. The EC₅₀ of tanerasertib ranges from 15 to 60 nM, making it applicable to cancer-related research.

Cas No. 3034255-93-8

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Tanerasertib is an AKT1 inhibitor that can specifically target the AKT1 E17K mutant. The EC₅₀ of tanerasertib ranges from 15 to 60 nM, making it applicable to cancer-related research.
Targets & IC50	Akt1 (E17K):15-60 nM (EC50)

Chemical Properties

Molecular Weight	597.65
Formula	C₃₃H₂₈FN₁₁
Cas No.	3034255-93-8
Smiles	N#CC1=NC=CC(=N1)NC2CCN(CC3=CC=C(C=C3)N4C=5N=C(C=CC5N=C4C6=CC=CN=C6N)C=7N=CC(F)=CC7)CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (13.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6732 mL	8.3661 mL	16.7322 mL	83.6610 mL
5 mM	0.3346 mL	1.6732 mL	3.3464 mL	16.7322 mL
10 mM	0.1673 mL	0.8366 mL	1.6732 mL	8.3661 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.