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Mc-VC-PAB-SN38

Name: Mc-VC-PAB-SN38
Brand: TargetMol
SKU: T39222
Price: 193 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39222Cas No. 1801838-28-7

Alias Mc-VC-PAB-SN38

Mc-VC-PAB-SN38 consists of a cleavable ADC linker (Mc-VC-PAB) and SN38, which is part of an antibody-coupled reactive molecule commonly used to synthesize antibody-coupled reactive molecules (ADCs) that target sites of action.

Mc-VC-PAB-SN38

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Purity: 99.22%

Catalog No. T39222Alias Mc-VC-PAB-SN38Cas No. 1801838-28-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$193	-	In Stock
5 mg	$488	-	In Stock
10 mg	$737	-	In Stock
25 mg	$1,090	-	In Stock
50 mg	$1,480	-	In Stock
100 mg	$1,980	-	In Stock
200 mg	$2,730	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.22%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	Mc-VC-PAB-SN38 consists of a cleavable ADC linker (Mc-VC-PAB) and SN38, which is part of an antibody-coupled reactive molecule commonly used to synthesize antibody-coupled reactive molecules (ADCs) that target sites of action.
In vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.[1]
Synonyms	Mc-VC-PAB-SN38

Chemical Properties

Molecular Weight	991.05
Formula	C₅₁H₅₈N₈O₁₃
Cas No.	1801838-28-7
Smiles	CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN5C(=O)C=CC5=O)C(C)C)cc4)c3=O)-c2nc2ccc(O)cc12
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (50.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0090 mL	5.0452 mL	10.0903 mL	50.4515 mL
5 mM	0.2018 mL	1.0090 mL	2.0181 mL	10.0903 mL
10 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0452 mL
20 mM	0.0505 mL	0.2523 mL	0.5045 mL	2.5226 mL
50 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc