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Mc-VC-PAB-SN38

Name: Mc-VC-PAB-SN38
Brand: TargetMol
SKU: T39222
Price: 193 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39222Cas No. 1801838-28-7

Alias Mc-VC-PAB-SN38

Mc-VC-PAB-SN38 consists of a cleavable ADC linker (Mc-VC-PAB) and SN38, which is part of an antibody-coupled reactive molecule commonly used to synthesize antibody-coupled reactive molecules (ADCs) that target sites of action.

Mc-VC-PAB-SN38

🥰Excellent

Purity: 98.59%

Catalog No. T39222Alias Mc-VC-PAB-SN38Cas No. 1801838-28-7

Pack Size	Price	Availability
1 mg	$193	In Stock
5 mg	$488	In Stock
10 mg	$737	In Stock
25 mg	$1,090	In Stock
50 mg	$1,480	In Stock
100 mg	$1,980	In Stock
200 mg	$2,730	In Stock

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Batch Information

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Purity:98.59%

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COA LCMS

Product Introduction

Bioactivity

Description	Mc-VC-PAB-SN38 consists of a cleavable ADC linker (Mc-VC-PAB) and SN38, which is part of an antibody-coupled reactive molecule commonly used to synthesize antibody-coupled reactive molecules (ADCs) that target sites of action.
In vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.[1]
Synonyms	Mc-VC-PAB-SN38

Chemical Properties

Molecular Weight	991.05
Formula	C₅₁H₅₈N₈O₁₃
Cas No.	1801838-28-7
Smiles	CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN5C(=O)C=CC5=O)C(C)C)cc4)c3=O)-c2nc2ccc(O)cc12
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (50.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0090 mL	5.0452 mL	10.0903 mL	50.4515 mL
5 mM	0.2018 mL	1.0090 mL	2.0181 mL	10.0903 mL
10 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0452 mL
20 mM	0.0505 mL	0.2523 mL	0.5045 mL	2.5226 mL
50 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc