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Chrysophanol 8-O-glucoside
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Catalog No. T3S0381Cas No. 13241-28-6
Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway
Chrysophanol 8-O-glucoside
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Purity: 99.67%
Catalog No. T3S0381Cas No. 13241-28-6
Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | In Stock | In Stock | |
| 5 mg | $98 | In Stock | In Stock | |
| 10 mg | $156 | In Stock | In Stock | |
| 25 mg | $258 | In Stock | In Stock | |
| 50 mg | $365 | In Stock | In Stock | |
| 100 mg | $481 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.67%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Chrysophanol 8-O-glucoside AI Summary
Chrysophanol 8-O-glucoside shows inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages, with an IC50 greater than 100,000 nM and 31.0% inhibition at a concentration of 100 µM. It enhances the proliferation of the MCF-7 cell line at concentrations of 1 µM, 3 µM, and 10 µM, with the most significant enhancement (111.1% of the control value) observed at 10 µM. The compound exhibits cytotoxicity against human Lu1, LNCAP, MCF-7 cells, and HUVEC, with an effective dose (ED50) greater than 5.0 µg/mL. Additionally, it has low potency in DPPH radical scavenging activity with an IC50 value greater than 100.0 µg/mL. Potent antiviral activity against Hepatitis B virus is noted, with a significant decrease in HBV DNA, surface antigen, and e antigen production in HepG2.2.15 cells, reflected by an IC50 value of 300.0 µg/mL and a Selectivity Index greater than 42.0. Lastly, Chrysophanol 8-O-glucoside inhibits alpha-glucosidase activity, with an IC50 value greater than 100,000 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway |
| Molecular Weight | 416.38 |
| Formula | C21H20O9 |
| Cas No. | 13241-28-6 |
| Smiles | Cc1cc(O)c2C(=O)c3c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cccc3C(=O)c2c1 |
| Relative Density. | 1.596g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.17 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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