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Dibenamine hydrochloride

🥰Excellent
Catalog No. T37906Cas No. 55-43-6

Dibenamine hydrochloride is a competitive and irreversible blocker of the β-adrenergic receptor.

Dibenamine hydrochloride
Other Forms of Dibenamine hydrochloride:
DibenamineT6916451-50-3
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Dibenamine hydrochloride

🥰Excellent
Purity: 96.43%
Catalog No. T37906Cas No. 55-43-6
Dibenamine hydrochloride is a competitive and irreversible blocker of the β-adrenergic receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$29In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:96.43%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Dibenamine hydrochloride is a competitive and irreversible blocker of the β-adrenergic receptor.
In vitro
The irreversible inhibitory effects of dibenamine on the noradrenaline-, K- and Ba-induced contractions of rat's isolated vas deferens, particularly in relation to Ca.
In vivo
Dibenamine hydrochloride causes a significant increase in the rate of destruction of L-epinephrine in the mouse. Pretreatment with Dibenamine hydrochloride apparently slowed the conversion of Ccl4 to CHCL3. Dibenamine hydrochloride (25 mg/kg; s.c.) decreased the CHCl3, levels at 2 and 6 hr by 30%-50%[3].
Chemical Properties
Molecular Weight296.23
FormulaC16H19Cl2N
Cas No.55-43-6
SmilesCl.ClCCN(Cc1ccccc1)Cc1ccccc1
Relative Density.1.107g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (421.97 mM), Sonication is recommended.
H2O: 33.33 mg/mL (112.51 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.5 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3758 mL16.8788 mL33.7576 mL168.7878 mL
5 mM0.6752 mL3.3758 mL6.7515 mL33.7576 mL
10 mM0.3376 mL1.6879 mL3.3758 mL16.8788 mL
20 mM0.1688 mL0.8439 mL1.6879 mL8.4394 mL
50 mM0.0675 mL0.3376 mL0.6752 mL3.3758 mL
100 mM0.0338 mL0.1688 mL0.3376 mL1.6879 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-adrenergic receptorInhibitorinhibithepatotoxicityepinephrineDibenamine hydrochlorideDibenamine HydrochlorideDibenamineBeta ReceptorAdrenergicReceptorAdrenergic ReceptoradrenergicAcetylcholine
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