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Anti-Phospho-p53 (Ser376) Antibody (4Q111) (Synonyms: p-p53 (Ser376), p-p53 (S376), p53 (p-Ser376), p53 (p-S3...)
Catalog No. TMAC-03242 Copy Product Info
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Anti-Phospho-p53 (Ser376) Antibody (4Q111) is a Rabbit antibody targeting Phospho-p53 (Ser376). Anti-Phospho-p53 (Ser376) Antibody (4Q111) can be used in WB.
Anti-Phospho-p53 (Ser376) Antibody (4Q111)
Copy Product Info🥰Excellent
Catalog No. TMAC-03242
Synonyms p-p53 (Ser376), p-p53 (S376), p53 (p-Ser376), p53 (p-S376)
Anti-Phospho-p53 (Ser376) Antibody (4Q111) is a Rabbit antibody targeting Phospho-p53 (Ser376). Anti-Phospho-p53 (Ser376) Antibody (4Q111) can be used in WB.
Anti-Phospho-p53
(Ser376) Antibody
(4Q111)
(Ser376) Antibody
(4Q111)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $497 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Phospho-p53 (Ser376) Antibody (4Q111) is a Rabbit antibody targeting Phospho-p53 (Ser376). Anti-Phospho-p53 (Ser376) Antibody (4Q111) can be used in WB. |
| Synonyms | p-p53 (Ser376), p-p53 (S376), p53 (p-Ser376), p53 (p-S376) |
| Ig Type | IgG |
| Clone | 4Q111 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Phospho-p53 (S376) on human skin lysates using anti-Phospho-p53 (S376) antibody at 1/1,000 dilution.  |
| Application | |
| Recommended Dose | WB: 1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human p53 around the phosphorylation site of Ser376 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 53 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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