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Spectinomycin dihydrochloride

Name: Spectinomycin dihydrochloride
Brand: TargetMol
SKU: T0788
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0788Cas No. 21736-83-4

Alias Spectinomycin 2HCl, Actinospectacin

Spectinomycin dihydrochloride (Actinospectacin) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Spectinomycin dihydrochloride

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Purity: 99.9%

Catalog No. T0788Alias Spectinomycin 2HCl, ActinospectacinCas No. 21736-83-4

Spectinomycin dihydrochloride (Actinospectacin) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$42	In Stock	In Stock
1 g	$53	In Stock	In Stock
2 g	$66	-	In Stock
5 g	$84	-	In Stock
10 g	$123	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.9%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Spectinomycin dihydrochloride AI Summary

Spectinomycin dihydrochloride exhibits multiple bioactivities according to provided data. It inhibits Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with a potency of 17782.8 nM. In assays related to GLP1 secretion from STC-1 and NCI-H716 cells, it has an IC50 of 40000.0 nM. Additionally, it blocks the entry of the Ebola Virus, showing an AC50 of 2.239 µM in one screening assay and AC50 values of 2238.7 nM and 1778.3 nM in different assays. However, Spectinomycin dihydrochloride demonstrates low activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.1494, indicating limited efficacy compared to the arbidol control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Spectinomycin dihydrochloride (Actinospectacin) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Synonyms	Spectinomycin 2HCl, Actinospectacin

Chemical Properties

Molecular Weight	405.271
Formula	C₁₄H₂₆Cl₂N₂O₇
Cas No.	21736-83-4
Smiles	Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
Relative Density.	1.43g/cm3

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 74 mg/mL (182.59 mM), Sonication is recommended.

DMSO: 242.5 mg/mL (598.37 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4675 mL	12.3374 mL	24.6748 mL	123.3742 mL
5 mM	0.4935 mL	2.4675 mL	4.9350 mL	24.6748 mL
10 mM	0.2467 mL	1.2337 mL	2.4675 mL	12.3374 mL
20 mM	0.1234 mL	0.6169 mL	1.2337 mL	6.1687 mL
50 mM	0.0493 mL	0.2467 mL	0.4935 mL	2.4675 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2337 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc