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YM-750

🥰Excellent
Catalog No. T23550Cas No. 138046-43-2
Alias YM 750

YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholesteryl esters.

YM-750

YM-750

🥰Excellent
Purity: 99.96%
Catalog No. T23550Alias YM 750Cas No. 138046-43-2
YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholesteryl esters.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$32In StockIn Stock
5 mg$48In StockIn Stock
10 mg$83In StockIn Stock
25 mg$167In StockIn Stock
50 mg$273In StockIn Stock
100 mg$394In StockIn Stock
200 mg$573In StockIn Stock
1 mL x 10 mM (in DMSO)$56In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholesteryl esters.
SynonymsYM 750
Chemical Properties
Molecular Weight452.63
FormulaC31H36N2O
Cas No.138046-43-2
SmilesCc1cc(C)c(NC(=O)N(Cc2ccc-3c(Cc4ccccc-34)c2)C2CCCCCC2)c(C)c1
Relative Density.1.15 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (220.93 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2093 mL11.0466 mL22.0931 mL110.4655 mL
5 mM0.4419 mL2.2093 mL4.4186 mL22.0931 mL
10 mM0.2209 mL1.1047 mL2.2093 mL11.0466 mL
20 mM0.1105 mL0.5523 mL1.1047 mL5.5233 mL
50 mM0.0442 mL0.2209 mL0.4419 mL2.2093 mL
100 mM0.0221 mL0.1105 mL0.2209 mL1.1047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

YM-750YM750stressoxidativemono- acylglycerol acyltransferaselevelsInhibitorinhibitfoamDiglyceride acyltransferaseDiacylglycerol acyltransferasecholesterolcellsanti-hyperlipidemicanti-atheroscleroticAcyltransferaseacyl-CoA:cholesterol acyltransferaseACAT
Related Tags: buy YM-750 | purchase YM-750 | YM-750 cost | order YM-750 | YM-750 chemical structure | YM-750 formula | YM-750 molecular weight
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