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Cysteamine hydrochloride

Name: Cysteamine hydrochloride
Brand: TargetMol
SKU: T6460
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: β-Mercaptoethylamine Hydrochloride, Thioethanolamine Hydrochloride, Cysteamine HCl, Bekaptan, 2-Mercaptoethylamine Hydrochloride, 2-Aminoethanethiol Hydrochloride) Copy Product Info

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Synonyms: β-Mercaptoethylamine Hydrochloride, Thioethanolamine Hydrochloride, Cysteamine HCl, Bekaptan, 2-Mercaptoethylamine Hydrochloride, 2-Aminoethanethiol Hydrochloride

Catalog No. T6460 Copy Product Info

Purity: 99.87%

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Cysteamine hydrochloride is an orally administered small-molecule drug commonly used for the treatment of nephropathic cystinosis. It also functions as an antioxidant and is used in experimental studies to induce gastrointestinal disorders, duodenal ulcers, and kidney injury models in mice.

Cas No. 156-57-0

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Information

Bioactivity

Description	Cysteamine hydrochloride is an orally administered small-molecule drug commonly used for the treatment of nephropathic cystinosis. It also functions as an antioxidant and is used in experimental studies to induce gastrointestinal disorders, duodenal ulcers, and kidney injury models in mice.
In vitro	Cysteamine enhances intracellular glutathione (GSH) levels in cystinotic cells, effectively restoring their altered redox state and demonstrating antioxidant capabilities by increasing glutathione production, thus scavenging harmful OH and HOCl. It also mitigates increased apoptosis rates in cystinotic cells by counteracting the effects of elevated caspase 3 and protein kinase Cε activity. Furthermore, Cysteamine boosts the production of various heat shock proteins (HSP), notably murine Hsp40. It exhibits a dose-dependent mitigation of doxorubicin-induced death in cancer cells, including HeLa and B16 cells, without affecting cell survival on its own. Remarkably, it enhances the efficacy of doxorubicin in doxorubicin-resistant breast cancer cells, significantly increasing cell death. Additionally, Cysteamine (100 μM) not only heightens intracellular GSH levels but also improves the development of matured oocytes to the blastocyst stage in embryo cultures. [1][2]
In vivo	Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1]
Synonyms	β-Mercaptoethylamine Hydrochloride, Thioethanolamine Hydrochloride, Cysteamine HCl, Bekaptan, 2-Mercaptoethylamine Hydrochloride, 2-Aminoethanethiol Hydrochloride
Disease Modeling Protocol	Ocular inflammation model Modeling Mechanism： Cysteamine hydrochloride inhibits the Notch signaling pathway and activates the Vegf signaling pathway, leading to abnormal proliferation of ocular vascular endothelial cells and disordered vascular morphology. At the same time, it induces oxidative stress overload, induces the production of large amounts of reactive oxygen species (ROS), recruits neutrophils to aggregate and triggers apoptosis, disrupts ocular homeostasis, and ultimately causes ocular inflammation mainly characterized by neutrophil chemotaxis. Modeling Method： Experimental Subject： zebrafish. Ddouble transgenic lines Tg(kdrl:mCherry; elavl3:EGFP), Tg(kdrl:mCherry; tp1: EGFP), Tg(fli:GFP; lyz:DsRed), and Tg(fli:GFP; mpeg1:mCherry). Dosage and Administration Route： CSH powder was dissolved in the culture solution at a concentration of 100 mM at room temperature as a stock solution and stored at 4 ℃. The zebrafish culture medium was then diluted to the concentration required for the experiment , and supplemented with 0.003% 1-phenyl-2-thiourea to inhibit skin pigmentation (PTU use was restricted to experiments requiring fluorescence photog_x0002_raphy and staining). Experimental groups included a blank control group (culture solution), a low concentration (L) group (0.18 mM CSH), a medium concentration (M) group (0.36 mM CSH), and a high concen_x0002_tration (H) group (0.54 mM CSH). Dosing Frequency and Duration Model： Three consecutive days with daily solution replacement. Validation： Elevated ROS levels and increased neutrophil aggregation were observed in ocular tissues. qPCR results showed upregulated expression of Vegf signaling pathway genes and significant inhibition of Notch receptor transcription. TUNEL assays revealed an increase in apoptotic cells. Precautions： A glucose tolerance test was performed by administering a 40% glucose solution (4 g per kilogram of body weight) orally after an overnight fast; rats in each group were euthanized at 0, 15, 30, 60, and 120 minutes. Plasma samples were collected to measure blood glucose, insulin, and glucagon levels. Pancreatic tissue was extracted with acidic ethanol to determine insulin and glucagon content. References：Chen C, et al. Cysteamine hydrochloride affects ocular development and triggers associated inflammation in zebrafish. J Hazard Mater. 2023 Oct 5;459:132175.

Chemical Properties

Molecular Weight	113.61
Formula	C₂H₇NS·HCl
Cas No.	156-57-0
Smiles	Cl.NCCS
Relative Density.	0.75

Storage & Solubility Information

Storage

Store under nitrogen,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 22 mg/mL (193.64 mM), Sonication is recommended.

H2O: 21 mg/mL (184.84 mM), Sonication is recommended.

DMSO: 71.43 mg/mL (628.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 7.14 mg/mL (62.85 mM), Solution.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (17.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	8.8020 mL	44.0102 mL	88.0204 mL	440.1021 mL
5 mM	1.7604 mL	8.8020 mL	17.6041 mL	88.0204 mL
10 mM	0.8802 mL	4.4010 mL	8.8020 mL	44.0102 mL
20 mM	0.4401 mL	2.2005 mL	4.4010 mL	22.0051 mL
50 mM	0.1760 mL	0.8802 mL	1.7604 mL	8.8020 mL
100 mM	0.0880 mL	0.4401 mL	0.8802 mL	4.4010 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ReactiveOxygenSpeciesReactive Oxygen SpeciesorallynephropathicInhibitorinhibitEndogenousMetaboliteEndogenous MetabolitecystinosisCysteamine hydrochlorideCysteamineb-Mercaptoethylamine Hydrochloridebeta-Mercaptoethylamine HydrochlorideAutophagyApoptosisantioxidant2-Mercaptoethylamine2-Aminoethanethiol

Related Tags: Cysteamine hydrochloride chemical structure | Cysteamine hydrochloride in vivo | Cysteamine hydrochloride in vitro | Cysteamine hydrochloride formula | Cysteamine hydrochloride molecular weight