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Anti-AXL Antibody (6X283)
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Catalog No. TMAY-03119
Alias AXL receptor tyrosine kinase
Anti-AXL Antibody (6X283) is a Rabbit antibody targeting AXL. Anti-AXL Antibody (6X283) can be used in ELISA(Det).
Anti-AXL Antibody (6X283)
Anti-AXL Antibody (6X283)
😃Good
Catalog No. TMAY-03119Alias AXL receptor tyrosine kinase
Anti-AXL Antibody (6X283) is a Rabbit antibody targeting AXL. Anti-AXL Antibody (6X283) can be used in ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $94 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-AXL Antibody (6X283) is a Rabbit antibody targeting AXL. Anti-AXL Antibody (6X283) can be used in ELISA(Det). |
| Alias | AXL receptor tyrosine kinase |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 6X283 |
| Reactivity | Mouse |
| Application | ELISA(Det) |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Axl Kinase (rM Axl Kinase; TMPY-01364; NP_033491.2; Met1-Pro443). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse Axl Kinase Protein (TMPY-01364) |
| Antigen Species | Mouse |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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