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Anti-Insulin Receptor R Polyclonal Antibody
Catalog No. TMAB-07730 Copy Product Info
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Anti-Insulin Receptor R Polyclonal Antibody is a Rabbit antibody targeting Insulin Receptor R. Anti-Insulin Receptor R Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Insulin Receptor R Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-07730
Anti-Insulin Receptor R Polyclonal Antibody is a Rabbit antibody targeting Insulin Receptor R. Anti-Insulin Receptor R Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Insulin Receptor R Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Insulin Receptor R Polyclonal Antibody is a Rabbit antibody targeting Insulin Receptor R. Anti-Insulin Receptor R Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (Human pancreatic cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Insulin Receptor R) Polyclonal Antibody, Unconjugated (TMAB-07730) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn’t bind any of IR and IGF-1R known ligands. In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown. |
| Immunogen | KLH conjugated synthetic peptide: human Insulin receptor-related protein beta chain |
| Antigen Species | Human |
| Gene Name | INSRR |
| Gene ID | |
| Protein Name | Insulin receptor-related protein |
| Uniprot ID | |
| Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
| Molecular Weight | Theoretical: 129 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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