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Mosapride

Name: Mosapride
Brand: TargetMol
SKU: T8128
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8128Cas No. 112885-41-3

Alias TAK-370, AS-4370

Mosapride (AS-4370) is a selective 5HT4 agonist

Mosapride

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Purity: 99.56%

Catalog No. T8128Alias TAK-370, AS-4370Cas No. 112885-41-3

Mosapride (AS-4370) is a selective 5HT4 agonist

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$44	In Stock	In Stock
25 mg	$71	In Stock	In Stock
50 mg	$101	-	In Stock
100 mg	$147	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Mosapride AI Summary

Mosapride exhibits diverse bioactivities across various biological targets and assays. Demonstrating antiemetic activity, it suppresses apomorphine-induced emesis in dogs at 1.0 mg/kg with an efficacy of 8.0% and affects gastric emptying rates in rats ranging from 37.0% to 79.0% depending on dose and meal type. It shows significant affinity for the 5-hydroxytryptamine 4 receptor (Ki = 69.9 nM) and moderate inhibition of the 5-hydroxytryptamine 3 receptor (Ki = 1189.0 nM), with no significant affinity for the Dopamine receptor D2. Additionally, it affects gastrointestinal motility and increases stomach motility by 188.0% in dogs. Mosapride inhibits human ERG channels and displays inhibitory effects on serotonin, adrenergic receptors, and CYP450 enzymes, suggesting potential drug-drug interaction risks. It impacts various physiological parameters including liver and kidney functions, glucose metabolism, and blood cell counts, and has shown moderate antiviral activity against SARS-CoV-2. While it also exhibits HDAC6 inhibitory activities, its overall enzyme and receptor binding at relevant concentrations often is weak, with many AC50 values above 30000.0 nM. The compound's multifaceted pharmacological profile indicates potential applications across various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mosapride (AS-4370) is a selective 5HT4 agonist
Synonyms	TAK-370, AS-4370

Chemical Properties

Molecular Weight	421.89
Formula	C₂₁H₂₅ClFN₃O₃
Cas No.	112885-41-3
Smiles	C(NCC1CN(CC2=CC=C(F)C=C2)CCO1)(=O)C3=C(OCC)C=C(N)C(Cl)=C3
Relative Density.	1.272 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.04 mg/mL (87.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (11.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3703 mL	11.8514 mL	23.7029 mL	118.5143 mL
5 mM	0.4741 mL	2.3703 mL	4.7406 mL	23.7029 mL
10 mM	0.2370 mL	1.1851 mL	2.3703 mL	11.8514 mL
20 mM	0.1185 mL	0.5926 mL	1.1851 mL	5.9257 mL
50 mM	0.0474 mL	0.2370 mL	0.4741 mL	2.3703 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc