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Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2
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Catalog No. TMAB-07024
Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 is a Rabbit antibody targeting HIF Prolyl Hydroxylases. Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 can be used in WB.
Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2
Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2
😃Good
Catalog No. TMAB-07024
Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 is a Rabbit antibody targeting HIF Prolyl Hydroxylases. Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 is a Rabbit antibody targeting HIF Prolyl Hydroxylases. Anti-HIF Prolyl Hydroxylases Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Pig) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human HIF Prolyl Hydroxylases |
| Antigen Species | Human |
| Gene Name | P4HTM |
| Gene ID | |
| Protein Name | Transmembrane prolyl 4-hydroxylase |
| Uniprot ID | |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Molecular Weight | Theoretical: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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