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Chelerythrine
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Catalog No. T6S0052Cas No. 34316-15-9
Alias Toddalin, Cheleritrine, Broussonpapyrine
1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiproliferative and antitumor effects.
Chelerythrine
Copy Product Info🥰Excellent
Purity: 99.96%
Catalog No. T6S0052Alias Toddalin, Cheleritrine, BroussonpapyrineCas No. 34316-15-9
1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiproliferative and antitumor effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $50 | In Stock | In Stock | |
| 10 mg | $86 | In Stock | In Stock | |
| 25 mg | $145 | In Stock | In Stock | |
| 50 mg | $217 | In Stock | In Stock | |
| 100 mg | $326 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $73 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.96%
Appearance:Solid
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Product Introduction
Chelerythrine AI Summary
Chelerythrine exhibits a broad spectrum of bioactivities across diverse biochemical pathways and functions. It acts as an agonist for the NFkB Signaling Pathway (potency of 11220.2 nM) and the Thyroid Stimulating Hormone Receptor (potency of 25118.9 nM), as well as a potent inhibitor of various targets including HSD17B4 (25118.9 nM), Tyrosyl-DNA Phosphodiesterase (TDP1) (63095.7 nM), human liver OATP2B1 (13.1% inhibition), and recombinant human DOPA decarboxylase enzyme (IC50 of 1280000.0 nM). It inhibits mitochondrial division or activates mitochondrial fusion (5804.8 nM) and enhances SMN2 Splice Variant Expression (7079.5 nM). Notably, Chelerythrine shows strong binding affinity to c-myc and c-Kit1 G-quadruplex DNA, demonstrating significant antiproliferative activity against several human cancer cell lines, with complete inhibition of viability at 20 uM concentration in MTT assays.
Additionally, Chelerythrine has pronounced antibacterial properties, effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus (MIC90 of 4.0 ug/mL), as well as vancomycin-resistant and vancomycin-sensitive Enterococcus faecalis (MIC90 of 32.0 ug/mL). It also inhibits Mycobacterium tuberculosis (MIC of 3.1 ug/mL). The compound displays competitive inhibition of human MAO-A (Ki of 220.0 nM) and MAO-B, favoring MAO-A with higher potency. It intervenes in cholinesterase activity, with IC50 values of 1450.0 nM for acetylcholinesterase (AChE) and 8580.0 nM for butyrylcholinesterase (BuChE), showing selectivity towards AChE.
Chelerythrine also demonstrates selective cytotoxicity across different cell lines, with the highest potency against LL24 cells and the least against A549 cells. It furthers its bioactivity by binding to the PPARgamma ligand-binding domain (IC50 of 566.0 nM) and inhibiting SERCA1a activity with varied potencies (1200.0 nM to 27000.0 nM). These diverse activities suggest that Chelerythrine may have potential therapeutic applications in cancer, bacterial infections, neurodegenerative diseases, and metabolic disorders..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiproliferative and antitumor effects. |
| Targets&IC50 | PKC:0.7 μM (IC50) |
| Synonyms | Toddalin, Cheleritrine, Broussonpapyrine |
| Molecular Weight | 348.37 |
| Formula | C21H18NO4 |
| Cas No. | 34316-15-9 |
| Smiles | C[N+]=1C=2C(C=3C(C1)=C(OC)C(OC)=CC3)=CC=C4C2C=C5C(=C4)OCO5 |
| Relative Density. | 1.2985 g/cm3 (Estimated) |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (31.58 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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