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Anti-AR/Androgen receptor Antibody (3C609) (ready to use)
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Catalog No. TMAB-02799
Anti-AR/Androgen receptor Antibody (3C609) is a Mouse antibody targeting AR/Androgen receptor. Anti-AR/Androgen receptor Antibody (3C609) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Anti-AR/Androgen receptor Antibody (3C609) (ready to use)
Anti-AR/Androgen receptor Antibody (3C609) (ready to use)
😃Good
Catalog No. TMAB-02799
Anti-AR/Androgen receptor Antibody (3C609) is a Mouse antibody targeting AR/Androgen receptor. Anti-AR/Androgen receptor Antibody (3C609) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 3 mL | $102 | 7-10 days | 7-10 days | |
| 6 mL | $185 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-AR/Androgen receptor Antibody (3C609) is a Mouse antibody targeting AR/Androgen receptor. Anti-AR/Androgen receptor Antibody (3C609) can be used in IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG2b |
| Clone | 3C609 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. Cytoplasm. Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1. |
| Tissue Specificity | Isoform 2 is mainly expressed in heart and skeletal muscle. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M PBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| Research Background | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human human Androgen Receptor |
| Antigen Species | Human |
| Gene Name | AR |
| Gene ID | |
| Protein Name | Androgen receptor |
| Uniprot ID | |
| Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3. |
| Molecular Weight | Theoretical: 101 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. |
| Transport | Shipping with blue ice. |
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