Anti-HDAC3 Polyclonal Antibody

Name: Anti-HDAC3 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00840
Rating: 4.5 (1 reviews)

(Synonyms: SMAP45, RPD3-2, Protein deacylase HDAC3, Protein deacetylase HDAC3, Histone deacetylase 3, HDAC3, HD3) Copy Product Info

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Synonyms: SMAP45, RPD3-2, Protein deacylase HDAC3, Protein deacetylase HDAC3, Histone deacetylase 3, HDAC3, HD3

Catalog No. TMAB-00840 Copy Product Info

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Anti-HDAC3 Polyclonal Antibody is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Polyclonal Antibody can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-HDAC3 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description	Anti-HDAC3 Polyclonal Antibody is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Polyclonal Antibody can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Synonyms	SMAP45, RPD3-2, Protein deacylase HDAC3, Protein deacetylase HDAC3, Histone deacetylase 3, HDAC3, HD3
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Chicken,Pig,Cow,Horse)

Application	ICC/IF IF IHC-Fr IHC-P WB
Recommended Dose	ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus.
Tissue Specificity	Widely expressed.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human HDAC3
Antigen Species	Human
Gene Name	HDAC3
Gene ID	8841
Protein Name	Histone deacetylase 3
Uniprot ID	O15379
Biology Area	Metabolism of lipids and lipoproteins,Tumor suppressors,Hypertrophy,Acetylation,Class I,Lipid metabolism,Cancer,HDACs
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.