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L-Hydroxyproline

Name: L-Hydroxyproline
Brand: TargetMol
SKU: T2A2476
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2A2476Cas No. 51-35-4

Alias Trans-4-Hydroxyproline, trans-4-Hydroxy-L-proline, L-Hydroxyprolin

L-Hydroxyproline (L-Hydroxyprolin) is one of the hydroxyproline (Hyp) isomers. L-Hydroxyproline is a useful chiral building block in the production of many pharmaceuticals.

L-Hydroxyproline

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Purity: 99.92%

Catalog No. T2A2476Alias Trans-4-Hydroxyproline, trans-4-Hydroxy-L-proline, L-HydroxyprolinCas No. 51-35-4

L-Hydroxyproline (L-Hydroxyprolin) is one of the hydroxyproline (Hyp) isomers. L-Hydroxyproline is a useful chiral building block in the production of many pharmaceuticals.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$29	In Stock	In Stock

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Purity:99.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

L-Hydroxyproline AI Summary

L-Hydroxyproline exhibits a broad spectrum of bioactivities and pharmacological properties. It shows significant affinity towards the carnitine/acylcarnitine translocase, with an experimental efflux value of 5346.0 DPM from isolated rat heart mitochondria. It inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells, with a Ki value of 9000000.0 nM and a pKi value of -0.95 mM. In oncology, L-Hydroxyproline demonstrates potent growth inhibition across a variety of human tumor cell lines, including breast, renal, non-small cell lung, leukemia, central nervous system, prostate, melanoma, ovarian, and colon, with a GI50 value of 100,000.0 nM. It also inhibits ASCT2 and ASCT1 transporters, as well as a D-serine transporter, affecting serine uptake in rat hippocampal astrocytes, rat visual cortex, and human HEK cells. In antiviral research, L-Hydroxyproline inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 33.43% at a concentration of 10 µM after 48 hours, though it shows a minimal inhibitory effect (-0.11%) in VERO-6 cells under similar conditions. It also demonstrates a 3.712% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. In enzymatic assays, it shows differential inhibitory activity against human HDAC6, with a 16.12% inhibition using a commercial peptide substrate, but a -1.23% inhibition using a custom substrate. Despite having weak activity towards various human receptors and enzymes, indicated by AC50 values greater than 30,000.0 nM, L-Hydroxyproline remains a compound of interest due to its diverse bioactivities and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Hydroxyproline (L-Hydroxyprolin) is one of the hydroxyproline (Hyp) isomers. L-Hydroxyproline is a useful chiral building block in the production of many pharmaceuticals.
Synonyms	Trans-4-Hydroxyproline, trans-4-Hydroxy-L-proline, L-Hydroxyprolin

Chemical Properties

Molecular Weight	131.13
Formula	C₅H₉NO₃
Cas No.	51-35-4
Smiles	OC1CNC(C1)C(O)=O
Relative Density.	1.395 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (1906.5 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.6260 mL	38.1301 mL	76.2602 mL	381.3010 mL
5 mM	1.5252 mL	7.6260 mL	15.2520 mL	76.2602 mL
10 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
20 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
50 mM	0.1525 mL	0.7626 mL	1.5252 mL	7.6260 mL
100 mM	0.0763 mL	0.3813 mL	0.7626 mL	3.8130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc