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Luxeptinib

Name: Luxeptinib
Brand: TargetMol
SKU: T37085
Rating: 4.5 (1 reviews)

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Catalog No. T37085Cas No. 1616428-23-9

Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].

Luxeptinib

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Catalog No. T37085Cas No. 1616428-23-9

Pack Size	Price	Availability
25 mg	$1,140	6-8 weeks
50 mg	$1,490	6-8 weeks
100 mg	$2,440	6-8 weeks

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Product Introduction

Bioactivity

Description

In vitro

Luxeptinib (MEC-1 CLL cells; 0.1~10 μM; 72 hours) inhibits cell proliferation with an IC50 of 32 nM[1]. It inhibits BCR signaling-induced phosphorylation of BTK, PLCg2, AKT, ERK1/2, and S6 ribosomal protein, and strongly suppresses SYK phosphorylation in primary chronic lymphocytic leukemia (CLL) cells[1]. Luxeptinib (MV4-11 cells; 500 pM; 1 hour) completely inhibits phosphorylation of FLT3 and STAT5[2].

Chemical Properties

Molecular Weight	495.43
Formula	C₂₅H₁₇F₄N₅O₂
Cas No.	1616428-23-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (252.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0184 mL	10.0922 mL	20.1845 mL	100.9224 mL
5 mM	0.4037 mL	2.0184 mL	4.0369 mL	20.1845 mL
10 mM	0.2018 mL	1.0092 mL	2.0184 mL	10.0922 mL
20 mM	0.1009 mL	0.5046 mL	1.0092 mL	5.0461 mL
50 mM	0.0404 mL	0.2018 mL	0.4037 mL	2.0184 mL
100 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc