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Anti-Crry Polyclonal Antibody
Catalog No. TMAB-04700 Copy Product Info
🥰Excellent
Anti-Crry Polyclonal Antibody is a Rabbit antibody targeting Crry. Anti-Crry Polyclonal Antibody can be used in WB.
Anti-Crry Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-04700
Anti-Crry Polyclonal Antibody is a Rabbit antibody targeting Crry. Anti-Crry Polyclonal Antibody can be used in WB.
Anti-Crry Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Crry Polyclonal Antibody is a Rabbit antibody targeting Crry. Anti-Crry Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Rat) |
| Verified Activity | 1. Protein: placenta (mouse) lyates at 40 μg; lymph node (mouse) lyates at 40 μg; Primary: Rabbit Anti-Crry (TMAB-04700) at 1:300; Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit Igg (H+L) at 1: 10000; Predicted band size:58 kD Observed band size:58 kD 2. Protein: bone (mouse) lyates at 40 μg; Primary: Rabbit Anti-Crry (TMAB-04700) at 1:300; Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit Igg (H+L) at 1: 10000; Predicted band size:58 kD Observed band size:58 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Human membrane cofactor protein (MCP), also designated CD46, is a widely distributed complement regulator. In mouse, expression of MCP is largely restricted to testis, while a related widely expressed protein (Crry) appears to perform the regulatory activity of MCP. Crry (for murine complement receptor-related gene Y), protects the body from damage inflicted by inflammation and modulates renal interstitial disease induced by proteinuria. A functional ortholog of human decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), Crry protects cells from homologous complement by inhibiting the complement proteins C3 and C4 convertases from marking foreign cells for destruction. Sequence analysis suggests that Crry may be the mouse genetic homolog of the CD35 antigen encoded by the human gene CR1. Manipulation of Crry may play a role in treating central nervous conditions such as traumatic brain injury or stroke. Deletion of the gene encoding Crry may play a role in miscarriages. |
| Immunogen | KLH conjugated synthetic peptide: mouse Crry |
| Antigen Species | Mouse |
| Gene Name | Cr1l |
| Gene ID | |
| Protein Name | Complement component receptor 1-like protein |
| Uniprot ID | |
| Function | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance. |
| Molecular Weight | Theoretical: 58 kDa. Actual: 58 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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