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Laurocapram

Name: Laurocapram
Brand: TargetMol
SKU: T2A2509
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2A2509Cas No. 59227-89-3

Alias Tranzone, N-Lauryl caprolactam, N-Dodecylcaprolactam, N-0252, Azone

Laurocapram (N-Lauryl caprolactam) is a percutaneous enhancer. Upon application to the skin, laurocapram interacts with lipids in the stratum corneum and may enhance the ability of the skin to absorb a hydrophilic chemical.

Laurocapram

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Purity: 98.91%

Catalog No. T2A2509Alias Tranzone, N-Lauryl caprolactam, N-Dodecylcaprolactam, N-0252, AzoneCas No. 59227-89-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
5 g	$42	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Laurocapram AI Summary

Laurocapram enhances the permeation of theophylline through human skin from water with an enhancement ratio of 2.5, but shows a lower enhancement ratio of 0.6 when the permeation is from an isopropyl myristate (IPM) suspension. Additionally, Laurocapram exhibits antiviral activity against SARS-CoV-2 by inhibiting the virus-induced cytotoxicity in VERO-6 cells, with an inhibition rate of -0.29% at a concentration of 10 µM after 48 hours of exposure to 0.01 MOI SARS-CoV-2 virus and an IC50 value greater than 20000 nM. Furthermore, the compound inhibits the SARS-CoV-2 3CL-Pro protease by 23.87% at a 20 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Laurocapram (N-Lauryl caprolactam) is a percutaneous enhancer. Upon application to the skin, laurocapram interacts with lipids in the stratum corneum and may enhance the ability of the skin to absorb a hydrophilic chemical.
Synonyms	Tranzone, N-Lauryl caprolactam, N-Dodecylcaprolactam, N-0252, Azone

Chemical Properties

Molecular Weight	281.48
Formula	C₁₈H₃₅NO
Cas No.	59227-89-3
Smiles	C(CCCCCCCCCCC)N1C(=O)CCCCC1
Relative Density.	0.906-0.926

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (177.63 mM), Sonication is recommended.

H2O: 100 mg/mL (355.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5527 mL	17.7633 mL	35.5265 mL	177.6325 mL
5 mM	0.7105 mL	3.5527 mL	7.1053 mL	35.5265 mL
10 mM	0.3553 mL	1.7763 mL	3.5527 mL	17.7633 mL
20 mM	0.1776 mL	0.8882 mL	1.7763 mL	8.8816 mL
50 mM	0.0711 mL	0.3553 mL	0.7105 mL	3.5527 mL
100 mM	0.0355 mL	0.1776 mL	0.3553 mL	1.7763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc