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Tirofiban hydrochloride monohydrate

Tirofiban hydrochloride monohydrate
Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist.
Catalog No. T2537Cas No. 150915-40-5
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Purity:99.94%
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Tirofiban hydrochloride monohydrate

Catalog No. T2537Cas No. 150915-40-5

Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$64In Stock
25 mg$120In Stock
50 mg$196In Stock
100 mg$326In Stock
500 mg$779In Stock
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Product Introduction

Bioactivity
Description
Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist.
Targets&IC50
ADP:70 ng/ml, Collagen:200 ng/ml, Thrombin:5,000 ng/ml
In vitro
METHODS: HUVEC cells were cultured in 24-well plates. The effect of 0.12, 0.25, 1, and 3 μg/ml Tirofiban(MK383) hydrochloride monohydrate on cell growth was determined using cell counting method. Cells were harvested after 72 h and counted using trypan blue.
RESULTS At a concentration of 0.25 μg/ml, the number of cells in the Tirofiban group increased compared with the group without Tirofiban. Tirofiban can induce the growth of HUVEC cells. [1]
METHODS:HUVEC cells were treated with Tirofiban (1mg/mL) at different time points (0, 1, 2, 3, 4 and 5 hours).
RESULTS After Tirofiban treatment, the amount of VEGF produced by HUVECs gradually increased and reached a peak at 2 hours. [2]
In vivo
METHODS: Rats were intravenously injected with Tirofiban(MK383) hydrochloride monohydrate (200 μg/kg). Fifteen minutes later, the left renal pedicle was occluded with a small microvascular forceps, and renal ischemia was induced for 45 minutes. Blood was collected 24 hours after reperfusion, and the left kidney was taken for analysis.
RESULTS Tirofiban can reduce SCR and BUN levels in I/R-injured kidneys, improve renal tissue pathological changes, and reduce ROS generation, cell apoptosis, and leukocyte infiltration. [3]
METHODS: 60 μg/kg Tirofiban was administered as an intravenous bolus injection through the tail vein of rats 30 minutes before reperfusion, and the cardiac function of the rats was observed.
RESULTS Tirofiban improved cardiac function, with lower left ventricular end-systolic blood pressure levels, left ventricular pressure maximum change rates of increase and decrease, heart rate, and left ventricular end-diastolic pressure levels. [4]
AliasTirofiban Hydrochloride, MK-383 Hydrochloride
Chemical Properties
Molecular Weight495.07
FormulaC22H39ClN2O6S
Cas No.150915-40-5
Storage & Solubility Information
Storagekeep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (101 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0199 mL10.0996 mL20.1992 mL100.9958 mL
5 mM0.4040 mL2.0199 mL4.0398 mL20.1992 mL
10 mM0.2020 mL1.0100 mL2.0199 mL10.0996 mL
20 mM0.1010 mL0.5050 mL1.0100 mL5.0498 mL
50 mM0.0404 mL0.2020 mL0.4040 mL2.0199 mL
100 mM0.0202 mL0.1010 mL0.2020 mL1.0100 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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