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Tormentic acid

Name: Tormentic acid
Brand: TargetMol
SKU: TN1118
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1118Cas No. 13850-16-3

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

Tormentic acid

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Purity: 99.86%

Catalog No. TN1118Cas No. 13850-16-3

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$255	In Stock	In Stock
25 mg	$433	In Stock	In Stock
50 mg	$628	-	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Tormentic acid AI Summary

Tormentic acid exhibits a range of biological activities and cytotoxic effects. Its key actions include cytotoxicity against various human cancer cell lines such as K562, Lucena1, MCF7, NCI-H460, HT-29, CEM, fibroblast cells, 8505C, A549, DLD1, HepG2, Bel7402, and SK-OV-3, with IC50 values ranging broadly and significant inhibition of cell proliferation demonstrated. This compound also shows moderate activity against HIV1 recombinant protease expressed in Escherichia coli, with 49.0% inhibition observed at 17.9 ug/mL. Additionally, it has antiviral activity against HIV1 3B in human H9 cells with an IC50 of 15.0 ug/mL as measured by p24 antigen ELISA. Moreover, Tormentic acid demonstrates anti-inflammatory properties by inhibiting nitric oxide production in mouse RAW264.7 cells with an IC50 value of 24900.0 nM, and neuroprotective effects in rat C6 cells by inducing nerve growth factor secretion. It also shows hepatoprotective activity against D-GaIN-induced toxicity in mouse hepatocytes, with an IC50 value of 9500.0 nM and potential applications in liver protection. Other notable activities include inhibition of recombinant human SENP1 and reduction of deSUMOylation of RanGAP1-SUMO1, reversal of platinum resistance in cisplatin-resistant human SK-OV-3 cells, and synergistic effects when combined with cisplatin. These extensive bioactivities suggest that Tormentic acid has potential therapeutic applications in cancer treatment, HIV inhibition, inflammation reduction, neuroprotection, and hepatoprotection..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

Chemical Properties

Molecular Weight	488.7
Formula	C₃₀H₄₈O₅
Cas No.	13850-16-3
Smiles	CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1(C)O)C(O)=O
Relative Density.	1.19g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (102.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0462 mL	10.2312 mL	20.4625 mL	102.3123 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL	20.4625 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL	10.2312 mL
20 mM	0.1023 mL	0.5116 mL	1.0231 mL	5.1156 mL
50 mM	0.0409 mL	0.2046 mL	0.4092 mL	2.0462 mL
100 mM	0.0205 mL	0.1023 mL	0.2046 mL	1.0231 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc