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NU2058

Name: NU2058
Brand: TargetMol
SKU: T3186
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3186Cas No. 161058-83-9

Alias O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine

NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.

NU2058

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Purity: 99.92%

Catalog No. T3186Alias O6-(Cyclohexylmethyl)guanine, O(6)-CyclohexylmethylguanineCas No. 161058-83-9

NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.

Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$48	In Stock
25 mg	$82	In Stock
50 mg	$127	In Stock
100 mg	$197	In Stock
200 mg	$292	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:99.92%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Targets&IC50	CDK2:17 μM, CDK1:26 μM, CDK2:12 μM (Ki)
Synonyms	O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine

Chemical Properties

Molecular Weight	247.3
Formula	C₁₂H₁₇N₅O
Cas No.	161058-83-9
Smiles	Nc1nc(OCC2CCCCC2)c2nc[nH]c2n1
Relative Density.	1.52 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (242.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0437 mL	20.2184 mL	40.4367 mL	202.1836 mL
5 mM	0.8087 mL	4.0437 mL	8.0873 mL	40.4367 mL
10 mM	0.4044 mL	2.0218 mL	4.0437 mL	20.2184 mL
20 mM	0.2022 mL	1.0109 mL	2.0218 mL	10.1092 mL
50 mM	0.0809 mL	0.4044 mL	0.8087 mL	4.0437 mL
100 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc