Shopping Cart
Remove All
Your shopping cart is currently empty
NU2058
Copy Product Info
😃Good
Catalog No. T3186Cas No. 161058-83-9
Alias O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
NU2058
Copy Product Info😃Good
Purity: 99.92%
Catalog No. T3186Alias O6-(Cyclohexylmethyl)guanine, O(6)-CyclohexylmethylguanineCas No. 161058-83-9
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $35 | In Stock | In Stock | |
| 25 mg | $71 | In Stock | In Stock | |
| 50 mg | $108 | In Stock | In Stock | |
| 100 mg | $163 | In Stock | In Stock | |
| 200 mg | $243 | In Stock | In Stock | |
| 500 mg | $397 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.92%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
NU2058 AI Summary
NU2058 exhibits a broad range of bioactivities, particularly as an inhibitor of various cyclin-dependent kinases (CDKs) and their respective cyclins. It shows inhibitory effects on Cyclin-dependent kinase 1-cyclin B1 and Cyclin-dependent kinase 2-cyclin A with IC50 values of 7000 nM and 17000 nM, respectively, and Ki values of 5000 nM and 12000 nM, respectively. The compound also demonstrates antiproliferative activity against MCF-7 human breast carcinoma cells with a GI50 value of 20000 nM and an IC50 value of 24200 nM after 3 days. Additionally, NU2058 exhibits antiviral activity against SARS-CoV-2 in VERO-6 cells with an inhibition of cytotoxicity by 51.93% at 10 µM after 48 hours. It shows limited inhibitory effects on AGT activity in HT-29 cell extract with an IC50 value greater than 1,000,000 nM. Moreover, the compound has antimycobacterial activity against Mycobacterium avium and Mycobacterium tuberculosis. Overall, these diverse bioactivities suggest that NU2058 has the potential as a multi-target inhibitor in various biological systems..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity. |
| Targets&IC50 | CDK1:26 μM, CDK2:12 μM (Ki), CDK2:17 μM |
| Synonyms | O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine |
| Molecular Weight | 247.3 |
| Formula | C12H17N5O |
| Cas No. | 161058-83-9 |
| Smiles | Nc1nc(OCC2CCCCC2)c2nc[nH]c2n1 |
| Relative Density. | 1.52 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (242.62 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy NU2058 | purchase NU2058 | NU2058 cost | order NU2058 | NU2058 chemical structure | NU2058 formula | NU2058 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.