Shopping Cart

Your shopping cart is currently empty

Allantoin

Name: Allantoin
Brand: TargetMol
SKU: T0925
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0925Cas No. 97-59-6

Alias Glyoxyldiureide, 5-Ureidohydantoin

Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations.

Allantoin

Copy Product Info

😃Good

Purity: 99.82%

Catalog No. T0925Alias Glyoxyldiureide, 5-UreidohydantoinCas No. 97-59-6

Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations.

Pack Size	Price	USA Warehouse	Global Warehouse
10 g	$30	-	In Stock
25 g	$40	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.82%

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Allantoin AI Summary

Allantoin exhibits a range of bioactivities, including inhibiting RGS12 GoLoco motif activity, the Vitamin D receptor, malarial parasite plastid, alpha-syn, and LPS-induced nitric oxide production in mouse RAW264.7 cells with an IC50 value of 500.0 nM. It also demonstrates growth inhibition in various human tumor cell lines such as breast, renal, lung, prostate, melanoma, leukemia, ovarian, central nervous system, and colon cell lines. At a concentration of 20 µM, Allantoin induces NGF production in rat C6 cells with an activity of 102.4% after 24 hours and shows 100.2% cytotoxicity assessed by MTT assay. Additionally, it inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells by 86.17% and 67.4% respectively at 10 µM. The compound exhibits antibacterial activities against Klebsiella pneumoniae (18.45%), Pseudomonas aeruginosa (15.75%), Staphylococcus aureus (12.16%), Escherichia coli (9.38%), with varying degrees of inhibition, and antifungal activity against Candida albicans (2.26%) but shows negative inhibition against Cryptococcus neoformans (-7.8%). Allantoin shows limited antiviral activity against SARS-CoV-2 as indicated by a low inhibition index of 0.03873 in Vero E6 cells, and an IC50 value greater than 20,000.0 nM, reflecting low potency. However, it has a hit score of 0.1646, suggesting some potential efficacy. Furthermore, Allantoin inhibits His-tagged human recombinant SHMT2 by 58.2% and shows low inhibitory activity against human HDAC6 enzyme with approximately 1.79% inhibition using a commercial peptide substrate and 2.33% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations.
Synonyms	Glyoxyldiureide, 5-Ureidohydantoin

Chemical Properties

Molecular Weight	158.12
Formula	C₄H₆N₄O₃
Cas No.	97-59-6
Smiles	N(C(N)=O)C1NC(=O)NC1=O
Relative Density.	1.71 g/cm3. Temperature:22 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (395.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3243 mL	31.6216 mL	63.2431 mL	316.2155 mL
5 mM	1.2649 mL	6.3243 mL	12.6486 mL	63.2431 mL
10 mM	0.6324 mL	3.1622 mL	6.3243 mL	31.6216 mL
20 mM	0.3162 mL	1.5811 mL	3.1622 mL	15.8108 mL
50 mM	0.1265 mL	0.6324 mL	1.2649 mL	6.3243 mL
100 mM	0.0632 mL	0.3162 mL	0.6324 mL	3.1622 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc