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Thiethylperazine dimaleate

Name: Thiethylperazine dimaleate
Brand: TargetMol
SKU: T17072
Price: 343 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17072Cas No. 1179-69-7

Alias Toresten, Thiethylperazine maleate, Norzine

Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects.

Thiethylperazine dimaleate

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Purity: 99.88%

Catalog No. T17072Alias Toresten, Thiethylperazine maleate, NorzineCas No. 1179-69-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$343	In Stock	In Stock
500 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects.
In vitro	Thiethylperazine dimaleate dimaleate is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects[2].
In vivo	In APP/PS1 mice, Thiethylperazine dimaleate (3 mg/kg; intramuscular injection) causes a significant reduction of Aβ42 levels[2].
Synonyms	Toresten, Thiethylperazine maleate, Norzine

Chemical Properties

Molecular Weight	631.76
Formula	C₃₀H₃₇N₃O₈S₂
Cas No.	1179-69-7
Smiles	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (79.14 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5829 mL	7.9144 mL	15.8288 mL	79.1440 mL
5 mM	0.3166 mL	1.5829 mL	3.1658 mL	15.8288 mL
10 mM	0.1583 mL	0.7914 mL	1.5829 mL	7.9144 mL
20 mM	0.0791 mL	0.3957 mL	0.7914 mL	3.9572 mL
50 mM	0.0317 mL	0.1583 mL	0.3166 mL	1.5829 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc