Anti-FZD3 Polyclonal Antibody is a Rabbit antibody targeting FZD3. Anti-FZD3 Polyclonal Antibody can be used in WB,ELISA.

IgG

Human,Rat

Sample:
Lane 1: Human SW480 cell Lysates
Lane 2: Human U-2 OS cell Lysates
Lane 3: Human A431 cell Lysates
Lane 4: Human SH-SY5Y cell Lysates
Primary: Anti-FZD3 (TMAB-06227) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 74 kDa
Observed band size: 70 kDa

WB: 1:500-1000; ELISA: 1:5000-10000

Polyclonal

Recombinant Protein: human FZD3 protein

Human

FZD3

Frizzled-3

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.