Shopping Cart

Your shopping cart is currently empty

Ticlopidine

Name: Ticlopidine
Brand: TargetMol
SKU: T4190
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T4190Cas No. 55142-85-3

Alias Ticlid, PCR 5332

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Ticlopidine

Copy Product Info

😃Good

Purity: 99.67%

Catalog No. T4190Alias Ticlid, PCR 5332Cas No. 55142-85-3

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$32	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$97	In Stock	In Stock
100 mg	$147	In Stock	In Stock
500 mg	$369	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.67%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ticlopidine AI Summary

Ticlopidine exhibits a diverse range of bioactivities, primarily pertaining to its antithrombotic and inhibitory effects on various enzymes and receptors. It demonstrates significant antiplatelet activity by inhibiting collagen and ADP-induced platelet aggregation in both human and rabbit platelet-rich plasma (PRP). Notably, it has an IC50 value of 3180.0 nM against ADP-induced aggregation in rabbits and exhibits inhibitory activities against thrombin-induced platelet aggregation with an IC50 of 1550000.0 nM. In mouse models, Ticlopidine shows an ID50 of 260.0 mg/kg for preventing acute thrombic death induced by collagen. The effective doses (ED50) for antithrombotic activity are 151.64 umol/kg-1 and 40.0 mg/kg-1 in mice. Additionally, it demonstrates high in vivo antithrombotic activity with a PD50 of 120.0 mg/kg and significant inhibition in collagen-induced assays in rats. The compound also shows substantial inhibitory effects on several cytochrome P450 enzymes, including CYP2B6, CYP2C19, CYP3A4, and others, indicating potential drug-drug interaction concerns. It has a Ki value of 200.0 nM for CYP2B6 and demonstrates time-dependent inhibition of CYP2C19 with a Ki of 3300.0 nM and a Kinact of 0.07 min-1. The compound also strongly inhibits human liver microsomal enzymes, with IC50 values of 210.0 nM and 70000.0 nM for CYP2B6 and CYP2C19, respectively. In terms of liver toxicity, Ticlopidine is associated with significant risk, exhibiting a Drug-Induced Liver Injury (DILI) severity score of 4.0. It shows moderate to high hepatotoxicity in markers such as ALT, ALP, AST, and others, contributing to its cytolytic and cholestatic liver toxicity profiles in clinical settings. Additionally, Ticlopidine demonstrates antiviral activity against SARS-CoV-2 and possesses antimicrobial properties, particularly against methicillin-resistant Staphylococcus aureus (MRSA). It shows moderate efficacy in reducing the minimum inhibitory concentration (MIC) and has potential as a therapeutic agent in infectious diseases. Overall, Ticlopidine has demonstrated a broad spectrum of bioactivities, making it a candidate for further pharmacological exploration while also presenting considerations for safety and interaction profiles..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
Synonyms	Ticlid, PCR 5332

Chemical Properties

Molecular Weight	263.79
Formula	C₁₄H₁₄ClNS
Cas No.	55142-85-3
Smiles	Clc1ccccc1CN1CCc2sccc2C1
Relative Density.	1.273 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (208.5 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7909 mL	18.9545 mL	37.9089 mL	189.5447 mL
5 mM	0.7582 mL	3.7909 mL	7.5818 mL	37.9089 mL
10 mM	0.3791 mL	1.8954 mL	3.7909 mL	18.9545 mL
20 mM	0.1895 mL	0.9477 mL	1.8954 mL	9.4772 mL
50 mM	0.0758 mL	0.3791 mL	0.7582 mL	3.7909 mL
100 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8954 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc