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TMPH

Name: TMPH
Brand: TargetMol
SKU: T60080
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60080Cas No. 849461-90-1

Alias 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.

TMPH

🥰Excellent

Purity: 99.78%

Catalog No. T60080Alias 2,2,6,6-Tetramethylpiperidin-4-yl heptanoateCas No. 849461-90-1

TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	-	In Stock
5 mg	$53	-	In Stock
10 mg	$80	-	In Stock
25 mg	$143	-	In Stock
50 mg	$227	-	In Stock
100 mg	$335	-	In Stock
200 mg	$473	-	In Stock
1 mL x 10 mM (in DMSO)	$52	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Resource Download

COA MS HNMR HPLC

Product Introduction

Bioactivity

Description	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.
In vitro	TMPH (100 nM) inhibits nAChR with an inhibition rate of 90% in Xenopus oocytes and suppresses AChR subtypes with IC50s of 1.0-390 nM[1].
In vivo	In the nicotine-induced mice model, nAChR-IN-1 (20 mg/kg; s.c.) increases locomotor activity without effects on body temperature. In the tail-flick and hot-plate mice model, nAChR-IN-1(0, 0.1, 1, 5 mg/kg; s.c.) blocks the antinociceptive effect of nicotine in the hot-plate and blocks antinociception in a time-dependent manner[1].
Synonyms	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Chemical Properties

Molecular Weight	269.42
Formula	C₁₆H₃₁NO₂
Cas No.	849461-90-1
Smiles	O(C(CCCCCC)=O)C1CC(C)(C)NC(C)(C)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7117 mL	18.5584 mL	37.1168 mL	185.5838 mL
5 mM	0.7423 mL	3.7117 mL	7.4234 mL	37.1168 mL
10 mM	0.3712 mL	1.8558 mL	3.7117 mL	18.5584 mL
20 mM	0.1856 mL	0.9279 mL	1.8558 mL	9.2792 mL
50 mM	0.0742 mL	0.3712 mL	0.7423 mL	3.7117 mL
100 mM	0.0371 mL	0.1856 mL	0.3712 mL	1.8558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc