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TMPH

Name: TMPH
Brand: TargetMol
SKU: T60080
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60080Cas No. 849461-90-1

Alias 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.

TMPH

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Purity: 99.78%

Catalog No. T60080Alias 2,2,6,6-Tetramethylpiperidin-4-yl heptanoateCas No. 849461-90-1

TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	-	In Stock
5 mg	$53	-	In Stock
10 mg	$80	-	In Stock
25 mg	$143	-	In Stock
50 mg	$227	-	In Stock
100 mg	$335	-	In Stock
200 mg	$473	-	In Stock
1 mL x 10 mM (in DMSO)	$52	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR MS HPLC

Product Introduction

Bioactivity

Description	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.
In vitro	TMPH (100 nM) inhibits nAChR with an inhibition rate of 90% in Xenopus oocytes and suppresses AChR subtypes with IC50s of 1.0-390 nM[1].
In vivo	In the nicotine-induced mice model, nAChR-IN-1 (20 mg/kg; s.c.) increases locomotor activity without effects on body temperature. In the tail-flick and hot-plate mice model, nAChR-IN-1(0, 0.1, 1, 5 mg/kg; s.c.) blocks the antinociceptive effect of nicotine in the hot-plate and blocks antinociception in a time-dependent manner[1].
Synonyms	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Chemical Properties

Molecular Weight	269.42
Formula	C₁₆H₃₁NO₂
Cas No.	849461-90-1
Smiles	O(C(CCCCCC)=O)C1CC(C)(C)NC(C)(C)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7117 mL	18.5584 mL	37.1168 mL	185.5838 mL
5 mM	0.7423 mL	3.7117 mL	7.4234 mL	37.1168 mL
10 mM	0.3712 mL	1.8558 mL	3.7117 mL	18.5584 mL
20 mM	0.1856 mL	0.9279 mL	1.8558 mL	9.2792 mL
50 mM	0.0742 mL	0.3712 mL	0.7423 mL	3.7117 mL
100 mM	0.0371 mL	0.1856 mL	0.3712 mL	1.8558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc