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Tempo

Name: Tempo
Brand: TargetMol
SKU: T5363
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5363Cas No. 2564-83-2

Alias 2,2,6,6-Tetramethylpiperidinooxy

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

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Purity: 99.90%

Catalog No. T5363Alias 2,2,6,6-TetramethylpiperidinooxyCas No. 2564-83-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Viscous

Color:White

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COA HNMR LCMS

Product Introduction

Tempo AI Summary

Tempo shows bioactivity across multiple domains, including protective, antimalarial, and antioxidant effects. In terms of protection, it safeguards V79 cells from both hydrogen peroxide (H2O2) and radiation, demonstrating a mean surviving fraction score of 3.5 after 1-hour H2O2 exposure and a radiation protection score of 4.2 against a 12-Gy dose. Additionally, Tempo exhibits potent antimalarial activity with IC50 values of 0.0027 μg/mL against Plasmodium falciparum strain NF54 and 0.0016 μg/mL against strain K1, as determined by the [3H]hypoxanthine incorporation assay. Despite its bioactivities, the compound shows low cytotoxicity against human A431 cells, with an IC50 greater than 300,000 nM according to the MTT assay and less than 50% inhibition at a concentration of 300 μM. Furthermore, Tempo demonstrates significant antioxidant properties with an ABTS radical scavenging activity IC50 value of 26.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.
Synonyms	2,2,6,6-Tetramethylpiperidinooxy

Chemical Properties

Molecular Weight	156.25
Formula	C₉H₁₈NO
Cas No.	2564-83-2
Smiles	CC1(C)CCCC(C)(C)N1[O]
Relative Density.	1 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (320 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4000 mL	32.0000 mL	64.0000 mL	320.0000 mL
5 mM	1.2800 mL	6.4000 mL	12.8000 mL	64.0000 mL
10 mM	0.6400 mL	3.2000 mL	6.4000 mL	32.0000 mL
20 mM	0.3200 mL	1.6000 mL	3.2000 mL	16.0000 mL
50 mM	0.1280 mL	0.6400 mL	1.2800 mL	6.4000 mL
100 mM	0.0640 mL	0.3200 mL	0.6400 mL	3.2000 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Tempo

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