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Rotundic acid

Name: Rotundic acid
Brand: TargetMol
SKU: T5S0506
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0506Cas No. 20137-37-5

Alias Rutundic acid

Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.

Rotundic acid

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Purity: 99.97%

Catalog No. T5S0506Alias Rutundic acidCas No. 20137-37-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$147	In Stock	In Stock
50 mg	$239	In Stock	In Stock
100 mg	$355	In Stock	In Stock
200 mg	$526	-	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Rotundic acid AI Summary

Rotundic acid exhibits cytotoxicity against various human cell lines, including MCF7, NCI-H460, HT-29, CEM, fibroblast, NCI-H446, HepG2, HeLa, SPC-A1, and A375 cells, with cytotoxic activity ranging from 78.0% to 106.0% at 10 µM after 48 hours. The IC50 values obtained from the MTT assay also indicate significant cytotoxicity, with lower IC50 values corresponding to higher cytotoxicity. Additionally, Rotundic acid acts as an inhibitor of human recombinant PTP1B, showing an IC50 value of 20100 nM after 30 minutes. It also demonstrates anticomplement activity by inhibiting hemolysis in sheep erythrocytes through the classic pathway with an activity of 0.19 mg/ml, and in New Zealand White rabbit erythrocytes through the alternative pathway with an activity of 0.341 mg/ml, indicating its potential as an anticomplement agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.
Synonyms	Rutundic acid

Chemical Properties

Molecular Weight	488.70
Formula	C₃₀H₄₈O₅
Cas No.	20137-37-5
Smiles	[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)[C@@]2(C)CO
Relative Density.	1.19 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245.00 mg/mL (501.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0462 mL	10.2312 mL	20.4625 mL	102.3123 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL	20.4625 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL	10.2312 mL
20 mM	0.1023 mL	0.5116 mL	1.0231 mL	5.1156 mL
50 mM	0.0409 mL	0.2046 mL	0.4092 mL	2.0462 mL
100 mM	0.0205 mL	0.1023 mL	0.2046 mL	1.0231 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc