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Quercitrin

Name: Quercitrin
Brand: TargetMol
SKU: T2871
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2871Cas No. 522-12-3

Alias Xanthaurine, Sophoretin, Quercetin 3-rhamnoside, Meletin, 3-rhamnosyl quercetin

Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German camomile, endive, and kiwi, which makes quercitrin a potential biomarker for the consumption of these food products.

Quercitrin

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Purity: 99.66%

Catalog No. T2871Alias Xanthaurine, Sophoretin, Quercetin 3-rhamnoside, Meletin, 3-rhamnosyl quercetinCas No. 522-12-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$158	In Stock	In Stock
500 mg	$392	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.66%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Quercitrin AI Summary

Quercitrin exhibits a broad spectrum of bioactivities across various biological targets and assays. It shows significant in vitro inhibitory activity towards aldose reductase derived from rat, calf, and human sources, with IC50 values as low as 150.0 nM, indicating potential for managing diabetic complications. Additionally, it demonstrates notable anti-malarial efficacy against Plasmodium falciparum with IC50 values between 32.9 and 39.4 ng/ml, and cytotoxic effects against several cell lines including KB 3-1, A549, MCF7, and BGC823, with varying degrees of potency. Furthermore, it acts as an antioxidant, scavenging superoxide radicals effectively with significant activity in both ABTS and DPPH radical scavenging assays, featuring a Trolox equivalent antioxidant capacity of 0.854 mM. This compound also exhibits substantial bioactivity as an inhibitor of multiple kinases such as Pim2 and AKR1C21, with respective IC50 values of 25000.0 nM and 33300.0 nM. Its anti-inflammatory potential is evidenced by inhibition of 15-lipoxygenase (IC50 of 79800.0 nM) and antineuroinflammatory activity in BV2 cells upon LPS induction. Quercitrin shows potent inhibition of dengue virus replication (IC50 of 1700.0 nM) and significant antiviral activity against the influenza virus and Dengue virus NS2B-NS3 proteases. It also inhibits the proliferation of various pathogenic fungi, such as Candida glabrata, with a minimum inhibitory concentration of 7.8 ug/mL. Additionally, it inhibits soluble epoxide hydrolase (sEH) non-competitively with an IC50 value of 11800.0 nM, and demonstrates inhibition of PTP1B (IC50 of 17.49 ug/mL), suggesting potential therapeutic applications in metabolic disorders. In terms of pharmacological activity, Quercitrin impacts platelet aggregation, demonstrates antidepressant activity in behavioral tests on rats, and shows minimal effects on COX1 and COX2 enzymes. It effectively modulates the function of norfloxacin-induced NorA efflux pumps in Staphylococcus aureus and inhibits alpha-amylase activity, indicating possible benefits in bacterial resistance and diabetes management, respectively. Overall, Quercitrin is a multifunctional compound with considerable therapeutic potential across numerous biomedical fields, including anti-diabetic, anti-malarial, cytotoxic, antioxidant, antiviral, and anti-inflammatory applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German camomile, endive, and kiwi, which makes quercitrin a potential biomarker for the consumption of these food products.
Synonyms	Xanthaurine, Sophoretin, Quercetin 3-rhamnoside, Meletin, 3-rhamnosyl quercetin

Chemical Properties

Molecular Weight	448.38
Formula	C₂₁H₂₀O₁₁
Cas No.	522-12-3
Smiles	C[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.3943 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (579.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	111.5126 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	22.3025 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL	11.1513 mL
20 mM	0.1115 mL	0.5576 mL	1.1151 mL	5.5756 mL
50 mM	0.0446 mL	0.2230 mL	0.4461 mL	2.2303 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc