Dox-btn2

Name: Dox-btn2
Brand: TargetMol
SKU: T87869
Rating: 4.5 (1 reviews)

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Catalog No. T87869Cas No. 3026061-31-1

Dox-btn2, a biotinylated derivative of Doxorubicin with a biotin label attached at the 3'-NH2 position, can be utilized for cell imaging. Unlike Doxorubicin, which primarily accumulates in the nucleus, Dox-btn2 is predominantly found in the cytoplasm [1].

Dox-btn2

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Catalog No. T87869Cas No. 3026061-31-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Dox-btn2, a biotinylated derivative of Doxorubicin with a biotin label attached at the 3'-NH2 position, can be utilized for cell imaging. Unlike Doxorubicin, which primarily accumulates in the nucleus, Dox-btn2 is predominantly found in the cytoplasm [1].
In vitro	Dox-btn2 (1 μM; 6 h; Exc=531/40 nm, Emi=593/40 nm) enables visualization in U2OS cells, assisting in mapping the in-situ interactions with DNA and chromatin proteins [1].

Chemical Properties

Molecular Weight	1017.1
Formula	C₄₈H₆₄N₄O₁₈S
Cas No.	3026061-31-1
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(CCOCCOCCOCCOCCNC(CCCC[C@H]4[C@@]5([C@](CS4)(NC(=O)N5)[H])[H])=O)=O)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C6C1C(=O)C=7C(C6=O)=C(OC)C=CC7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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