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Anti-PKN2 Antibody (7R455)
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Catalog No. TMAH-00987
Alias Serine/threonine-protein kinase N2, Protein-kinase C-related kinase 2, Protein kinase C-like 2, PRKCL2, PRK2, PKN gamma, PKN 2, EC 2.7.11.13
Anti-PKN2 Antibody (7R455) is an antibody targeting PKN2. Anti-PKN2 Antibody (7R455) can be used in ELISA, WB, FCM.
Anti-PKN2 Antibody (7R455)
Anti-PKN2 Antibody (7R455)
😃Good
Catalog No. TMAH-00987Alias Serine/threonine-protein kinase N2, Protein-kinase C-related kinase 2, Protein kinase C-like 2, PRKCL2, PRK2, PKN gamma, PKN 2, EC 2.7.11.13
Anti-PKN2 Antibody (7R455) is an antibody targeting PKN2. Anti-PKN2 Antibody (7R455) can be used in ELISA, WB, FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB, FCM Reactivity: Human |
| Alias | Serine/threonine-protein kinase N2, Protein-kinase C-related kinase 2, Protein kinase C-like 2, PRKCL2, PRK2, PKN gamma, PKN 2, EC 2.7.11.13 |
| Ig Type | Rabbit IgG |
| Clone | 7R455 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate -All lanes: EBI3 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 140 kDa -Observed band size: 140 kDa 2. Overlay Peak curve showing HepG2 cells stained with TMAH-00987 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, WB, FCM |
| Recommended Dose | WB:1:500-1:2000; FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis. (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PKN2 |
| Antigen Species | Human |
| Gene ID | 5586 |
| Uniprot ID | |
| Biology Area | Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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