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Anti-Cubilin Antibody (2A269)

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Catalog No. TMAB-04779

Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-Cubilin Antibody (2A269)

Anti-Cubilin Antibody (2A269)

😃Good
Catalog No. TMAB-04779
Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2637-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
2A269
Reactivity
Human
Application
WB
IHC-P
IHC-Fr
IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationEndosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
Tissue SpecificityExpressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.
Concentration1mg/ml
Research BackgroundCubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Cubilin co-localizes with and binds to Megalin, a 600kDa member of the LDL receptor family that is required for the internalization of cubilin-bound ligands, such as vitamin B12, apolipoprotein A1 and Albumin. Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12.
Antigen Details
Immunogen
Recombinant Protein: human Cubilin protein
Antigen Species
Human
Gene Name
CUBN
Gene ID
8029
Protein Name
Cubilin
Uniprot ID
O60494
Chemical Properties
Molecular WeightTheoretical: 395 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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