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Anti-Cubilin Antibody (2A269)
Catalog No. TMAB-04779 Copy Product Info
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Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Cubilin Antibody (2A269)
Copy Product Info🥰Excellent
Catalog No. TMAB-04779
Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Cubilin Antibody
(2A269)
(2A269)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 2A269 |
| Reactivity | Human |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Cubilin Monoclonal Antibody, Unconjugated (TMAB-04779) at 1: 200 overnight at 4°C, followed by conjugation to the Goat Anti-Rabbit IgG H&L Secondary Antibody-HRP and DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. |
| Tissue Specificity | Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300. |
| Concentration | 1mg/ml |
| Research Background | Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Cubilin co-localizes with and binds to Megalin, a 600kDa member of the LDL receptor family that is required for the internalization of cubilin-bound ligands, such as vitamin B12, apolipoprotein A1 and Albumin. Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12. |
| Immunogen | Recombinant Protein: human Cubilin protein |
| Antigen Species | Human |
| Gene Name | CUBN |
| Gene ID | |
| Protein Name | Cubilin |
| Uniprot ID |
| Molecular Weight | Theoretical: 395 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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