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Diprotin A

Name: Diprotin A
Brand: TargetMol
SKU: T25340
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25340Cas No. 90614-48-5

Alias Ile-Pro-Ile

Diprotin A (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.

Diprotin A

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Purity: 99.29%

Catalog No. T25340Alias Ile-Pro-IleCas No. 90614-48-5

Diprotin A (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$94	In Stock	In Stock
100 mg	$142	In Stock	In Stock
200 mg	$198	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

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COA MS HPLC

Product Introduction

Diprotin A AI Summary

Diprotin A exhibits a varied inhibition profile across multiple enzymes and biochemical assays. Notably, it inhibits Cholecystokinin-8-Inactivating Peptidase with a Ki value of 1000.0 nM. It demonstrates strong inhibition of the conversion of the prodrug Val-Pro-NAP-TSAO-T to NAP-TSAO-T, catalyzed by bovine serum (>80%), CD26 enzyme (70%), and human serum (>80%). In terms of dipeptidyl peptidase inhibition, Diprotin A inhibits pig DPP4 with an IC50 of 14400.0 nM and human recombinant DPP4 with an IC50 of 3000.0 nM. It also inhibits DPP8 with a Ki of 39000.0 nM. Additionally, it shows weaker inhibition of DPP4 (14.0%) and DPP8 (10.0%) at 10 µM concentrations. For endomorphin degradation, it has Ki values of 2200.0 nM and significantly increases the half-life of endomorphin-2 and endomorphin-1. Furthermore, Diprotin A inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells at 10 µM concentrations, with inhibition percentages exceeding 100%. It also demonstrates potent inhibitory effects on JMJD2A-Tudor Domain (79,432.8 nM) and induces DNA re-replication in MCF 10a cells at a potency of 14,581.0 nM. Despite its various activities, it shows minimal inhibition of SARS-CoV-2 3CL-Pro protease and cytotoxicity induced by SARS-CoV-2 in VERO-6 cells. These properties suggest a potential therapeutic candidate for conditions involving serine peptidases, peptidyl peptidase inhibition, and antiviral applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diprotin A (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
Synonyms	Ile-Pro-Ile

Chemical Properties

Molecular Weight	341.45
Formula	C₁₇H₃₁N₃O₄
Cas No.	90614-48-5
Smiles	CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O
Relative Density.	1.14 g/cm3
Sequence	H-Ile-Pro-Ile-OH
Sequence Short	IPI

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (161.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9287 mL	14.6434 mL	29.2869 mL	146.4343 mL
5 mM	0.5857 mL	2.9287 mL	5.8574 mL	29.2869 mL
10 mM	0.2929 mL	1.4643 mL	2.9287 mL	14.6434 mL
20 mM	0.1464 mL	0.7322 mL	1.4643 mL	7.3217 mL
50 mM	0.0586 mL	0.2929 mL	0.5857 mL	2.9287 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc