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Artemitin
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🥰Excellent
Catalog No. TCS1704Cas No. 479-90-3
Alias Erianthin, Artemisetin, Artemetin
1. Artemitin (Erianthin) has anti-inflammatory activity. 2. Artemitin (Erianthin) protects endothelial function by acting as antioxidant and antiapoptotic agent and through the activation of ERK1/2 and Akt. 3. Intravenous injection of Artemitin (Erianthin)(.75 mg/kg) significantly reduces the hypertensive response to angiotensin I while increases the average length of bradykinin-induced hypotension.
Artemitin
Copy Product Info🥰Excellent
Purity: 99.83%
Catalog No. TCS1704Alias Erianthin, Artemisetin, ArtemetinCas No. 479-90-3
1. Artemitin (Erianthin) has anti-inflammatory activity. 2. Artemitin (Erianthin) protects endothelial function by acting as antioxidant and antiapoptotic agent and through the activation of ERK1/2 and Akt. 3. Intravenous injection of Artemitin (Erianthin)(.75 mg/kg) significantly reduces the hypertensive response to angiotensin I while increases the average length of bradykinin-induced hypotension.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | In Stock | In Stock | |
| 5 mg | $81 | In Stock | In Stock | |
| 10 mg | $123 | In Stock | In Stock | |
| 25 mg | $208 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $70 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.83%
Color:White to Yellow
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Product Introduction
Artemitin AI Summary
Artemitin exhibits multifaceted bioactivity, including antiproliferative and apoptotic effects against HL60 cells with IC50 and AC50 values of 6440.0 nM and 7260.0 nM, respectively. It demonstrates significant antibacterial activity with MIC values of 25.0-50.0 μg/mL against various bacterial strains, notably Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, though higher MIC values (>50.0 μg/mL) are observed for Streptococcus faecalis, Candida albicans, Sporothrix schenckii, and Aspergillus fumigatus. The compound also shows antifungal effects, with a particularly low MIC of 12.5 μg/mL against Cryptococcus neoformans.
In terms of antioxidant capacity, Artemitin has a total oxyradical scavenging capacity of 1.55, relative to Trolox at 0.28. It exerts cytotoxic effects on human HCT116 (GI50 of 2.2 μg/mL) and rat PC12 cells (GI50 of 2.27 μg/mL), and inhibits human HepG2, SH-SY5Y, and mouse S17 cells with an IC50 of 229000.0 nM, as measured by MTT assay.
Furthermore, the compound exhibits antitubercular activity against Mycobacterium tuberculosis H37Rv with a MIC of 185600.0 nM after 2 weeks and displays anti-inflammatory effects by inhibiting FMLP/CB-induced superoxide-anion generation and elastase release in human neutrophils (IC50 > 10.0 μg/mL).
In cardiovascular investigations, Artemitin shows a positive inotropic effect in Sprague-Dawley rat ventricular myocytes, with increases in cell contractility by 8.7% and 21.6% at concentrations of 10 and 50 μM, respectively. Additionally, it exhibits antitrypanosomal activity against Trypanosoma brucei rhodesiense with an EC50 of 12100.0 nM and a selectivity index of 9.8.
Lastly, the compound shows antibacterial activity against methicillin-resistant Staphylococcus aureus 1199B with an MIC of 256.0 μg/mL..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Artemitin (Erianthin) has anti-inflammatory activity. 2. Artemitin (Erianthin) protects endothelial function by acting as antioxidant and antiapoptotic agent and through the activation of ERK1/2 and Akt. 3. Intravenous injection of Artemitin (Erianthin)(.75 mg/kg) significantly reduces the hypertensive response to angiotensin I while increases the average length of bradykinin-induced hypotension. |
| Synonyms | Erianthin, Artemisetin, Artemetin |
| Molecular Weight | 388.37 |
| Formula | C20H20O8 |
| Cas No. | 479-90-3 |
| Smiles | COc1ccc(cc1OC)-c1oc2cc(OC)c(OC)c(O)c2c(=O)c1OC |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 18.52 mg/mL (47.69 mM), Sonication is recommended.  | |||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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