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TargetMol | Compound Library

Drug Repurposing Compound Library

Catalog No. L9200

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

The Drug Repurposing Compound Library by TargetMol, containing 4960 approved and clinical drugs, which have undergone extensive preclinical studies and have well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization, is a good tool for drug repurposing and cell induction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9200

Drug Repurposing Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 4960 approved and clinical drugs for high throughput screening (HTS) and high content screening (HCS);
  • An effective tool for discovering new with old drugs, cell induction, and new drug target screening;
  • All approved drugs collected in this library are approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), or included in the US Pharmacopeia (USP) Dictionary, the British Pharmacopoeia (BP), the European Pharmacopoeia (EP), the Japanese Pharmacopoeia (JP), or Chinese Pharmacopoeia (CP) Dictionary;
  • Covers various research areas, such as cancer, cardiovascular disease, immunology, respiratory system, etc.
  • Covers various targets, such as 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc.
  • Detailed compound information with structure, target, activity, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality.

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s Drug Repurposing Compound Library is built on rigorous inclusion standards to ensure that every compound in the library has a well-defined structure and high purity, verified by multiple analytical techniques such as NMR, HPLC, and LC-MS. Through a multi-step screening process, we eliminate compounds with undefined structures, including mixtures and polymers, as well as non-active agents such as sunscreens, contrast agents, and inorganic substances. The library exclusively includes small-molecule drugs and drug candidates that are either FDA-approved or currently in clinical trials. Compounds that have not yet entered the clinical phase are excluded, ensuring the safety of the library and enhancing the efficiency of drug repurposing efforts. This approach helps shorten the drug development cycle. Additionally, accurate compound information and clear classification significantly improve screening efficiency and reduce unnecessary resource and time costs.

Significant Structural Diversity

TargetMol’s Drug Repurposing Compound Library exhibits remarkable structural diversity, offering substantial advantages in drug discovery. Based on MACCS fingerprint analysis, the library can be categorized into 4,017 classes, effectively covering a broad chemical space. The library includes a wide variety of compounds, ranging from simple to highly complex chemical structures. This diversity provides a wealth of possibilities for identifying lead compounds with high affinity and specificity for target proteins, significantly advancing drug innovation.

 Drug Repurposing Compound Library
Library Diversity Analysis

Diverse Compound Collection

TargetMol’s Drug Repurposing Compound Library features not only a high degree of chemical diversity but also broad representation in terms of biological functions. The library includes compounds targeting key signaling pathways such as kinases, G protein-coupled receptors (GPCRs), ion channels, and epigenetic regulators. It comprehensively covers a wide range of disease areas including cancer, immune disorders, neurological diseases, metabolic diseases, and infectious diseases. The library contains 2,800+ approved drugs and 1,800+ clinical-stage drug candidates, including 190+ natural products that have entered clinical trials and 540+ natural products approved for market use. This library offers a rich and diverse chemical space, enabling researchers to explore new therapeutic strategies and accelerate the discovery of innovative drugs.

 Drug Repurposing Compound Library
Pathways Composition
 Drug Repurposing Compound Library
Disease Types
 Drug Repurposing Compound Library  Drug Repurposing Compound Library
Compound Categories

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files | TargetMol Supporting Files

Sci Citations

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
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Library Customization | TargetMol Library Composition

Autophagy
Antibacterial
Apoptosis
Antibiotic
Endogenous Metabolite
5-HT Receptor
Adrenergic Receptor
AChR
Dopamine Receptor
Histamine Receptor
COX
HIV Protease
Parasite
DNA/RNA Synthesis
Sodium Channel
Antifungal
Potassium Channel
Calcium Channel
VEGFR
EGFR
Topoisomerase
PDE
Glucocorticoid Receptor
PI3K
Reactive Oxygen Species
SARS-CoV
Cytochromes P450
Estrogen/progestogen Receptor
Dehydrogenase
CDK
Influenza Virus
HCV Protease
FLT
GABA Receptor
Ferroptosis
PPAR
NF-κB
Microtubule Associated
JAK
PDGFR
FGFR
Estrogen Receptor/ERR
HDAC
c-Kit
RAAS
Prostaglandin Receptor
c-Met/HGFR
mTOR
HBV
Mitophagy
Androgen Receptor
Src
Adenosine Receptor
Nucleoside Antimetabolite/Analog
Reverse Transcriptase
Tyrosine Kinases
iGluR
NMDAR
Serotonin Transporter
TRP/TRPV Channel
Bcr-Abl
Cholinesterase (ChE)
HSV
Norepinephrine
GPR
Proteasome
Virus Protease
GluR
PARP
MAO
Raf
ATPase
Antiviral
TNF
Progesterone Receptor
HSP
ribosome
Antioxidant
Phosphatase
ROS
Epigenetic Reader Domain
Akt
Carbonic Anhydrase
Transferase
p38 MAPK
Opioid Receptor
HIF/HIF Prolyl-Hydroxylase
ALK
Beta Amyloid
PKC
Aurora Kinase
IL Receptor
MMP
P-gp
Proton pump
Histone Methyltransferase
MEK
Antifection
DPP-4
c-RET
HER
DNA Alkylator/Crosslinker
Drug Metabolite
Mitochondrial Metabolism
Interleukin
TLR
AMPK
Monoamine Oxidase
Thyroid hormone receptor(THR)
ERK
Endothelin Receptor
Thrombin
Trk receptor
Bcl-2 Family
STAT
HMG-CoA Reductase
GSK-3
MRP
P2X Receptor
Lipoxygenase
Retinoid Receptor
c-Fms
HIF
Integrin
Caspase
ROCK
CCR
CXCR
SGLT
Phospholipase
TAM Receptor
NO Synthase
S1P Receptor
PKA
Chk
FAK
p53
DNA-PK
NADPH
Factor Xa
Wnt/beta-catenin
Serine Protease
E1/E2/E3 Enzyme
DNA Alkylation
Cannabinoid Receptor
Syk
CFTR
LPL Receptor
Reductase
Antifolate
Gamma-secretase
Guanylate cyclase
Nrf2
ATM/ATR
Neurokinin receptor
DHFR
Amino Acids and Derivatives
P2Y Receptor
Histone Demethylase
Glutathione Peroxidase
FXR
Hedgehog/Smoothened
IGF-1R
TGF-beta/Smad
RSV
Sigma receptor
ROS Kinase
BTK
Chloride channel
ADC Cytotoxin
CSF-1R
IAP
DNA gyrase
Hydroxylase
PLK
Tyrosinase
NOS
CETP
ABC Transporter
OX Receptor
CaMK
Indoleamine 2,3-Dioxygenase (IDO)
DNA Methyltransferase
NOD
S6 Kinase
Mdm2
BACE
JNK
Cysteine Protease
Leukotriene Receptor
Glucosidase
Smo
Vasopressin Receptor
Xanthine Oxidase
DNA
Sirtuin
Ligand for E3 Ligase
Kinesin
GNRH Receptor
Pim
Glucokinase
Aryl Hydrocarbon Receptor
RIP kinase
Glucagon Receptor
Monoamine Transporter
Beta-Secretase
Acyltransferase
Aminopeptidase
Casein Kinase
Aromatase
ROR
Cholecystokinin Receptor
GlyT
Molecular Glues
Isocitrate Dehydrogenase (IDH)
Fatty Acid Synthase
PAK
PGE Synthase
MAPK
GPCR19
IκB/IKK
GHSR
CGRP Receptor
Gap Junction Protein
IRAK
AhR
LTR
IFNAR
Liver X Receptor
IDO
MT Receptor
FAAH
Ephrin Receptor
CRFR
Complement System
NADPH-oxidase
Imidazoline Receptor
PROTACs
CRM1
DprE1
YAP
Cell wall
Tie-2
Melatonin Receptor
Serine/threonin kinase
Annexin A
UGT
Neuropeptide Y Receptor
Wee1
Lipid
OAT
STING
Decarboxylase
Neprilysin
GST
Acetyl-CoA Carboxylase
Kras
LPA Receptor
PDK
Anti-infection
Ras
Protease-activated Receptor
NOD-like Receptor (NLR)
PD-1/PD-L1
MicroRNA
Monocarboxylate transporter
NEDD8
Arginase
PERK
CaSR
Rho
PYK2
NAMPT
Glutaminase
Myosin
LDL
Na-K-Cl cotransporter
Bradykinin Receptor
Somatostatin
Epoxide Hydrolase
KSP
DUB
Telomerase
Free radical scavengers
transporter
Adenosine Deaminase
Vitamin
Apelin receptor
Advanced Glycation End Products
Taste receptor
GSNOR
Ligands for Target Protein for PROTAC
Na+/Ca2+ Exchanger
Lipase
TOPK
VDA
c-Myc
Galectin
IRE1
FLAP
Hexokinase
Integrase
HCN Channel
Stearoyl-CoA Desaturase (SCD)
Thrombopoietin Receptor
ATP Citrate Lyase
BCRP
Glutathione reductase
Porcupine
CD73
GluCls
PAI-1
Melanocortin Receptor
Oxytocin Receptor
Aquaporin
Discoidin Domain Receptor (DDR)
p97
MLK
Adenylyl Cyclase
NPC1L1
Hydrogenase
RAR/RXR
MALT
Dynamin
DYRK
gp120/CD4
GTPase
N-Acetylglucosaminyltransferase
AAK1
VDAC
Hck
LIM Kinase
Neurotensin Receptor
Stemness kinase
Immunology/Inflammation related
SIK
Adiponectin Receptor
PAFR
MTH1
Fas/FasL
GRK
Phosphorylase
Anion Exchanger
PROTAC Linker
Thioredoxin
ACK1
Angiotensin-converting Enzyme (ACE)
PAD
cAMP
Mucin
Huntingtin
MNK
Survivin
Histone Acetyltransferase
ASK
Pyroptosis
MELK
Methionine Adenosyltransferase (MAT)
Hippo pathway
KLF
PI4K
CRISPR/Cas9
RXFP receptor
SGK
Platelet aggregation
BMI-1
PKM