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TargetMol | Compound Library

Drug Repurposing Compound Library

Catalog No. L9200

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

The Drug Repurposing Compound Library by TargetMol, containing 5010 approved and clinical drugs, which have undergone extensive preclinical studies and have well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization, is a good tool for drug repurposing and cell induction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9200

Drug Repurposing Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 5010 approved and clinical drugs for high throughput screening (HTS) and high content screening (HCS);
  • An effective tool for discovering new with old drugs, cell induction, and new drug target screening;
  • All approved drugs collected in this library are approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), or included in the US Pharmacopeia (USP) Dictionary, the British Pharmacopoeia (BP), the European Pharmacopoeia (EP), the Japanese Pharmacopoeia (JP), or Chinese Pharmacopoeia (CP) Dictionary;
  • Covers various research areas, such as cancer, cardiovascular disease, immunology, respiratory system, etc.
  • Covers various targets, such as 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc.
  • Detailed compound information with structure, target, activity, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality.

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s Drug Repurposing Compound Library is built on rigorous inclusion standards to ensure that every compound in the library has a well-defined structure and high purity, verified by multiple analytical techniques such as NMR, HPLC, and LC-MS. Through a multi-step screening process, we eliminate compounds with undefined structures, including mixtures and polymers, as well as non-active agents such as sunscreens, contrast agents, and inorganic substances. The library exclusively includes small-molecule drugs and drug candidates that are either FDA-approved or currently in clinical trials. Compounds that have not yet entered the clinical phase are excluded, ensuring the safety of the library and enhancing the efficiency of drug repurposing efforts. This approach helps shorten the drug development cycle. Additionally, accurate compound information and clear classification significantly improve screening efficiency and reduce unnecessary resource and time costs.

Significant Structural Diversity

TargetMol’s Drug Repurposing Compound Library exhibits remarkable structural diversity, offering substantial advantages in drug discovery. Based on MACCS fingerprint analysis, the library can be categorized into 4,017 classes, effectively covering a broad chemical space. The library includes a wide variety of compounds, ranging from simple to highly complex chemical structures. This diversity provides a wealth of possibilities for identifying lead compounds with high affinity and specificity for target proteins, significantly advancing drug innovation.

 Drug Repurposing Compound Library
Library Diversity Analysis

Diverse Compound Collection

TargetMol’s Drug Repurposing Compound Library features not only a high degree of chemical diversity but also broad representation in terms of biological functions. The library includes compounds targeting key signaling pathways such as kinases, G protein-coupled receptors (GPCRs), ion channels, and epigenetic regulators. It comprehensively covers a wide range of disease areas including cancer, immune disorders, neurological diseases, metabolic diseases, and infectious diseases. The library contains 2,800+ approved drugs and 1,800+ clinical-stage drug candidates, including 190+ natural products that have entered clinical trials and 540+ natural products approved for market use. This library offers a rich and diverse chemical space, enabling researchers to explore new therapeutic strategies and accelerate the discovery of innovative drugs.

 Drug Repurposing Compound Library
Pathways Composition
 Drug Repurposing Compound Library
Disease Types
 Drug Repurposing Compound Library  Drug Repurposing Compound Library
Compound Categories

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage Packaging And Storage

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Apoptosis
Antibacterial
Autophagy
Antibiotic
Endogenous Metabolite
5-HT Receptor
Adrenergic Receptor
AChR
Parasite
Dopamine Receptor
DNA/RNA Synthesis
Histamine Receptor
COX
Potassium Channel
HIV Protease
Sodium Channel
Calcium Channel
Antifungal
VEGFR
Reactive Oxygen Species
Cytochromes P450
EGFR
Topoisomerase
PDE
SARS-CoV
Glucocorticoid Receptor
PI3K
NF-κB
Virus Protease
CDK
Estrogen/progestogen Receptor
Influenza Virus
Dehydrogenase
HCV Protease
FLT
Ferroptosis
PPAR
GABA Receptor
Microtubule Associated
FGFR
JAK
PDGFR
Estrogen Receptor/ERR
iGluR
c-Kit
HDAC
c-Met/HGFR
HBV
mTOR
Prostaglandin Receptor
RAAS
TNF
Mitophagy
Akt
Nucleoside Antimetabolite/Analog
Androgen Receptor
Cholinesterase (ChE)
Serotonin Transporter
Reverse Transcriptase
p38 MAPK
Interleukin
Caspase
HSV
Src
Tyrosine Kinases
Adenosine Receptor
NMDAR
Bcr-Abl
TRP/TRPV Channel
Bcl-2 Family
GPCR
Norepinephrine
ERK
MMP
Ras
HIF/HIF Prolyl-Hydroxylase
ATPase
GluR
PARP
MAO
Proteasome
HSP
Drug Metabolite
Raf
Beta Amyloid
Progesterone Receptor
Phosphatase
ribosome
Antiviral
Monoamine Oxidase
Epigenetic Reader Domain
Opioid Receptor
ROS
Antioxidant
ALK
Proton pump
P-gp
Mitochondrial Metabolism
Carbonic Anhydrase
Transferase
STAT
Aurora Kinase
IL Receptor
PKC
AMPK
TLR
NO Synthase
Angiotensin-converting Enzyme (ACE)
MEK
Anti-infection
MDM-2/p53
Histone Methyltransferase
Antifection
DNA Alkylator/Crosslinker
DPP-4
HER
Thyroid hormone receptor(THR)
c-RET
c-Fms
Endothelin Receptor
HMG-CoA Reductase
Nrf2
JNK
Phospholipase
LPL Receptor
CXCR
Serine Protease
Trk receptor
Thrombin
Lipoxygenase
ROS Kinase
GSK-3
TGF-beta/Smad
MRP
Retinoid Receptor
Gamma-secretase
Wnt/beta-catenin
E1/E2/E3 Enzyme
ROCK
HIF
P2X Receptor
FAK
Amino Acids and Derivatives
S1P Receptor
CCR
IGF-1R
SGLT
GNRH Receptor
Neurokinin receptor
TAM Receptor
Antifolate
Leukotriene Receptor
p53
Chk
CFTR
NADPH
Integrin
PKA
FXR
Cannabinoid Receptor
Syk
Kras
Sigma receptor
Molecular Glues
Vasopressin Receptor
Reductase
DNA Alkylation
ATM/ATR
Glutathione Peroxidase
Guanylate cyclase
Hydroxylase
ADC Cytotoxin
Factor Xa
DHFR
DNA-PK
DNA gyrase
Tyrosinase
P2Y Receptor
RSV
Histone Demethylase
S6 Kinase
NOD-like Receptor (NLR)
BTK
Glucosidase
Hedgehog/Smoothened
OX Receptor
Indoleamine 2,3-Dioxygenase (IDO)
NOS
PLK
IAP
Sirtuin
IDO
CaMK
DNA Methyltransferase
Isocitrate Dehydrogenase (IDH)
CSF-1R
IκB/IKK
Kinesin
Chloride channel
Xanthine Oxidase
MAPK
ABC Transporter
NOD
Beta-Secretase
Aminopeptidase
Aryl Hydrocarbon Receptor
Monoamine Transporter
Casein Kinase
Mdm2
Cholecystokinin Receptor
Smo
Ligand for E3 Ligase
RIP kinase
Fatty Acid Synthase
Cysteine Protease
Glucokinase
GPCR19
Complement System
DNA
BACE
Pim
PAK
Aromatase
GHSR
IRAK
Tie-2
Acyltransferase
GlyT
PGE Synthase
Melatonin Receptor
Serine/threonin kinase
ROR
Glucagon Receptor
OAT
PROTACs
FAAH
Telomerase
AhR
Photosensitizer
Liver X Receptor
Gap Junction Protein
PD-1/PD-L1
IKZF
CRM1
UGT
Thrombopoietin Receptor
Bradykinin Receptor
CGRP Receptor
NADPH-oxidase
LTR
PERK
Imidazoline Receptor
IFNAR
CETP
MT Receptor
Lipid
CaSR
Ephrin Receptor
CRFR
GST
Melanocortin Receptor
Oxytocin Receptor
ASBT
PYK2
Glutaminase
Wee1
Cuproptosis
Protease-activated Receptor
MTP
DprE1
OXPHOS
STING
Acetyl-CoA Carboxylase
FKBP
Vitamin
YAP
Cell wall
Annexin A
Na-K-Cl cotransporter
Neuropeptide Y Receptor
LPA Receptor
PDK
c-Myc
Myosin
Decarboxylase
Neprilysin
Somatostatin
Mucin
BCRP
Discoidin Domain Receptor (DDR)
Monocarboxylate transporter
LDL
Epoxide Hydrolase
KSP
Free radical scavengers
Apelin receptor
MicroRNA
Galectin
Immunology/Inflammation related
Hexokinase
DUB
NEDD8
ATP Citrate Lyase
Necroptosis
Stearoyl-CoA Desaturase (SCD)
transporter
Arginase
Rho
NAMPT
TOPK
Adenosine Deaminase
Neurotensin Receptor
Survivin
Aquaporin
p97
IRE1
Huntingtin
GluCls
Pyroptosis
MLK
Ligands for Target Protein for PROTAC
Lipase
PAFR
VDA
NR4A
Porcupine
CD73
Advanced Glycation End Products
SGK
GSNOR
Na+/Ca2+ Exchanger
HCN Channel
Histone Acetyltransferase
PAI-1
Taste receptor
FLAP
Integrase
Glutathione reductase
Adenylyl Cyclase
MIF
PAD
ASK
Methionine Adenosyltransferase (MAT)
MALT
Arrestin
Prolyl Endopeptidase (PREP)
MAGL
PTEN
Cadherin
RXFP receptor
PKM
Dynamin
LIM Kinase
MTH1
HCAR
MNK
PI4K
KLF
Hydrogenase
Factor VIIa
N-Acetylglucosaminyltransferase
VDAC
ATG
Adiponectin Receptor
Anion Exchanger
PROTAC Linker
Hippo pathway
p62
CRISPR/Cas9
OCT
Bcl-6
Hck
Stemness kinase
Fas/FasL
GRK
AAK1 (AP2 associated kinase 1)
Phosphorylase
Arp2/3 Complex
BMI-1
DYRK
gp120/CD4
GTPase
cAMP
MELK
Platelet aggregation
NPC1L1
Kisspeptin
AAK1
SIK
Thioredoxin
FOXO
Ferroportin