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Anti-HER3/ERBB3 Antibody (5O888)
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Catalog No. TMAY-00451
Alias erb-b2 receptor tyrosine kinase 3
Anti-HER3/ERBB3 Antibody (5O888) is a Mouse antibody targeting HER3/ERBB3. Anti-HER3/ERBB3 Antibody (5O888) can be used in ELISA(Cap).
Anti-HER3/ERBB3 Antibody (5O888)
Anti-HER3/ERBB3 Antibody (5O888)
😃Good
Catalog No. TMAY-00451Alias erb-b2 receptor tyrosine kinase 3
Anti-HER3/ERBB3 Antibody (5O888) is a Mouse antibody targeting HER3/ERBB3. Anti-HER3/ERBB3 Antibody (5O888) can be used in ELISA(Cap).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Chemical Properties
| Description | Anti-HER3/ERBB3 Antibody (5O888) is a Mouse antibody targeting HER3/ERBB3. Anti-HER3/ERBB3 Antibody (5O888) can be used in ELISA(Cap). |
| Alias | erb-b2 receptor tyrosine kinase 3 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5O888 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of Human ErbB3 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human ErbB3 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cell membrane. 2. Flow cytometric analysis of human ErbB3 expression on MCF-7 cells. Cells were stained with purified anti-Human ErbB3, then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA(Cap) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HER3 / ErbB3 (rh HER3 / ErbB3; TMPY-01389; NP_001973.2; Met1-Thr643). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | PE |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human HER3 / ErbB3 protein (TMPY-01389) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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