Shopping Cart
Remove All
Your shopping cart is currently empty
Agaric acid
Copy Product Info
😃Good
Catalog No. T14140Cas No. 666-99-9
Alias Agaricinic Acid
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.
Agaric acid
Copy Product Info😃Good
Purity: 98.99%
Catalog No. T14140Alias Agaricinic AcidCas No. 666-99-9
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | In Stock | In Stock | |
| 25 mg | $41 | In Stock | In Stock | |
| 50 mg | $66 | In Stock | In Stock | |
| 100 mg | $98 | In Stock | In Stock | |
| 500 mg | $236 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:98.99%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Agaric acid AI Summary
Agaric acid demonstrates broad-spectrum bioactivity with potential therapeutic implications. In vitro, it inhibits rat squalene synthase with an IC50 of 9000 nM. In vivo, when administered orally at 48 mpk in mice, it shows 0.0% inhibition of hepatic cholesterol synthesis. Additionally, it has shown significant inhibitory effects on multiple targets, including Bloom's syndrome helicase, GCN5L2, vitamin D receptor, Polymerase Kappa, Marburg Virus entry, USP1/UAF1, and the degranulation process in rat RBL2H3 cells (36% at 25 µM after 30 minutes). It also inhibits wild type His-tagged translin/trax E126A mutant in E. coli BL21 cells (58% at 30 µM over 60 minutes). The compound is effective in suppressing growth of various human tumor cell lines and induces DNA re-replication in normal breast cells. Furthermore, it inhibits glutaminase, demonstrates selectivity in impairing refolding mediated by specific chaperone systems, and exhibits significant inhibitory effects on MDH and rhodanese enzymes in their denatured states. These data indicate that Agaric acid has a diverse and potent inhibitory profile across multiple biological pathways and conditions..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism. |
| Synonyms | Agaricinic Acid |
| Molecular Weight | 416.55 |
| Formula | C22H40O7 |
| Cas No. | 666-99-9 |
| Smiles | CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(CC(O)=O)C(O)=O |
| Relative Density. | 1.0867 g/cm3 (Estimated) |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.17 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Agaric acid | purchase Agaric acid | Agaric acid cost | order Agaric acid | Agaric acid chemical structure | Agaric acid formula | Agaric acid molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.