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Palbociclib hydrochloride (Alias: TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride||...)
Catalog No. T63576 Copy Product Info
Purity: 99.89%
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Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
Palbociclib hydrochloride
Copy Product Info😃Good
Catalog No. T63576
Alias TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride
Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
Cas No. 571189-11-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $47 | In Stock | In Stock | |
| 10 mg | $68 | In Stock | In Stock | |
| 25 mg | $79 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:99.89%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma. |
| Targets&IC50 | MAPK:8000 nM, Dyrk1A:2000 nM, CDK4-CyclinD1:11 nM, CDK6-CyclinD2:16 nM, CDK4-CyclinD3:9 nM |
| In vitro | Methods: Huh7 and skHep1 cells were treated with Palbociclib hydrochloride (0.1, 0.5 μM, 10 days) to test the reversibility of cell cycle arrest. Results: Palbociclib hydrochloride may induce irreversible cell cycle arrest in both cell lines, which may be dose-dependent. [2] |
| In vivo | Methods: Palbociclib hydrochloride (40 mg/kg, oral, 17 days) was used to treat NSG mice bearing IMR32 neuroblastoma cells to study its effect on tumor growth in mice. Results: Palbociclib hydrochloride effectively inhibited tumor growth in NSG mice and had no obvious toxicity to mice. [1] |
| Synonyms | TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride |
| Molecular Weight | 520.46 |
| Formula | C24H31Cl2N7O2 |
| Cas No. | 571189-11-2 |
| Smiles | Cl.Cl.CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: 1 mg/mL (1.92 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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