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Palbociclib hydrochloride
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Catalog No. T63576Cas No. 571189-11-2
Alias TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride
Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
Palbociclib hydrochloride
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Purity: 99.89%
Catalog No. T63576Alias TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochlorideCas No. 571189-11-2
Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $47 | In Stock | In Stock | |
| 10 mg | $68 | In Stock | In Stock | |
| 25 mg | $79 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma. |
| Targets&IC50 | CDK6-CyclinD2:16 nM, CDK4-CyclinD3:9 nM, CDK4-CyclinD1:11 nM, Dyrk1A:2000 nM, MAPK:8000 nM |
| In vitro | Methods: Huh7 and skHep1 cells were treated with Palbociclib hydrochloride (0.1, 0.5 μM, 10 days) to test the reversibility of cell cycle arrest. Results: Palbociclib hydrochloride may induce irreversible cell cycle arrest in both cell lines, which may be dose-dependent. [2] |
| In vivo | Methods: Palbociclib hydrochloride (40 mg/kg, oral, 17 days) was used to treat NSG mice bearing IMR32 neuroblastoma cells to study its effect on tumor growth in mice. Results: Palbociclib hydrochloride effectively inhibited tumor growth in NSG mice and had no obvious toxicity to mice. [1] |
| Synonyms | TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride |
| Molecular Weight | 520.46 |
| Formula | C24H31Cl2N7O2 |
| Cas No. | 571189-11-2 |
| Smiles | Cl.Cl.CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O |
| Storage | keep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: 1 mg/mL (1.92 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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