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Loganin

Name: Loganin
Brand: TargetMol
SKU: T2759
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2759Cas No. 18524-94-2

Alias Loganoside

Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitory effects on melanogenesis.

Loganin

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Purity: 99.9%

Catalog No. T2759Alias LoganosideCas No. 18524-94-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$48	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$197	In Stock	In Stock
500 mg	$496	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Loganin AI Summary

Loganin exhibits diverse bioactivities, including antiviral, anti-inflammatory, cytotoxic, and enzyme inhibitory properties. Specifically, it inhibits viral entry of HCV in human Huh7 cells and Vpr-deficient HIV vectors, showing antiviral activity with significant inhibition rates at various exposure times and an IC50 value of 16.0 µg/mL after 72 hours based on NS5A staining. It also shows inhibition of LPS-induced NF-KB transcriptional activity in HEK-293 cells, demonstrating moderate inhibitory effects at 1 µg/mL and stronger effects at higher concentrations. Furthermore, Loganin exhibits cytotoxic activity against several human cell lines (e.g., MCF7, PA1, Caco2, WRL68, COLO320) with IC50 values ranging from 1.0 to 6.45 µg/mL, and shows toxicity against Bacopa monnieri. The compound strongly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 µM. Additionally, it acts as a COX1 and COX2 inhibitor, reducing PGH2 production in a dose-dependent manner. Loganin also inhibits IL-6-induced STAT3 activation in human HepG2 cells with an IC50 value of 14,000 nM and acts as a beta secretase inhibitor with a Ki value of 55,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitory effects on melanogenesis.
Targets&IC50	BACE1:47.97 μM, BChE:33.02 μM, AChE:3.95 μM
Synonyms	Loganoside

Chemical Properties

Molecular Weight	390.38
Formula	C₁₇H₂₆O₁₀
Cas No.	18524-94-2
Smiles	COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]2[C@@H](C)[C@@H](O)C[C@H]12
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (640.4 mM), Sonication is recommended.

H2O: 20 mg/mL (51.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5616 mL	12.8080 mL	25.6161 mL	128.0803 mL
5 mM	0.5123 mL	2.5616 mL	5.1232 mL	25.6161 mL
10 mM	0.2562 mL	1.2808 mL	2.5616 mL	12.8080 mL
20 mM	0.1281 mL	0.6404 mL	1.2808 mL	6.4040 mL
50 mM	0.0512 mL	0.2562 mL	0.5123 mL	2.5616 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0256 mL	0.1281 mL	0.2562 mL	1.2808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc