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Rapanone

Name: Rapanone
Brand: TargetMol
SKU: TN4893
Price: 233 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN4893Cas No. 573-40-0

Alias 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Rapanone

🥰Excellent

Purity: 99.56%

Catalog No. TN4893Alias 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinoneCas No. 573-40-0

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
Targets&IC50	PLA2:2.6 μM
In vitro	In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1].
In vivo	In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model
Synonyms	2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Chemical Properties

Molecular Weight	322.44
Formula	C₁₉H₃₀O₄
Cas No.	573-40-0
Smiles	CCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Relative Density.	1.099 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (201.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1014 mL	15.5068 mL	31.0135 mL	155.0676 mL
5 mM	0.6203 mL	3.1014 mL	6.2027 mL	31.0135 mL
10 mM	0.3101 mL	1.5507 mL	3.1014 mL	15.5068 mL
20 mM	0.1551 mL	0.7753 mL	1.5507 mL	7.7534 mL
50 mM	0.0620 mL	0.3101 mL	0.6203 mL	3.1014 mL
100 mM	0.0310 mL	0.1551 mL	0.3101 mL	1.5507 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc