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Rapanone

Name: Rapanone
Brand: TargetMol
SKU: TN4893
Price: 233 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN4893Cas No. 573-40-0

Alias 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Rapanone

🥰Excellent

Purity: 99.56%

Catalog No. TN4893Alias 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinoneCas No. 573-40-0

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.56%

Appearance:Solid

Color:Orange

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
Targets&IC50	PLA2:2.6 μM
In vitro	In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1].
In vivo	In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model
Synonyms	2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Chemical Properties

Molecular Weight	322.44
Formula	C₁₉H₃₀O₄
Cas No.	573-40-0
Smiles	CCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Relative Density.	1.099 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (201.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1014 mL	15.5068 mL	31.0135 mL	155.0676 mL
5 mM	0.6203 mL	3.1014 mL	6.2027 mL	31.0135 mL
10 mM	0.3101 mL	1.5507 mL	3.1014 mL	15.5068 mL
20 mM	0.1551 mL	0.7753 mL	1.5507 mL	7.7534 mL
50 mM	0.0620 mL	0.3101 mL	0.6203 mL	3.1014 mL
100 mM	0.0310 mL	0.1551 mL	0.3101 mL	1.5507 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc