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4-CMTB

Name: 4-CMTB
Brand: TargetMol
SKU: T8642
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8642Cas No. 300851-67-6

4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).

4-CMTB

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Purity: 99.59%

Catalog No. T8642Cas No. 300851-67-6

4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
2 mg	$59	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$140	In Stock	In Stock
25 mg	$243	In Stock	In Stock
50 mg	$359	In Stock	In Stock
100 mg	$533	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$93	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

4-CMTB AI Summary

4-CMTB has agonist activity at the human FFA2 receptor expressed in CHO cells, inhibiting forskolin-induced cAMP production with an IC50 of 800.0 nM and showing an efficacy of 98.0% relative to acetate. Additionally, it has diverse bioactivities across various assays: it is cytotoxic to Streptococcus with an EC50 > 150000.0 nM and to SK(-)GAS Group A Streptococcus with an EC50 of 12662.0 nM; modulates Lamin A splicing with a potency of 11220.2 nM; and acts as an inhibitor of multiple targets including mitochondrial division or activator of mitochondrial fusion (35481.3 nM), ROR gamma transcriptional activity (19952.6 - 14125.4 nM), Streptokinase promotor activity (20387.0 nM), malarial parasite plastid (9285.0 - 3696.4 nM), HP1-beta chromodomain interactions (89125.1 nM), Polymerase Iota (89125.1 nM), TGF-b (1995.3 nM), Marburg Virus entry (6309.6 nM), Hepatitis C Virus (31622.8 nM), GLP-1 receptor inverse agonists (10000.0 nM), HIV-1 protein Vpr (56234.1 nM), human tyrosyl-DNA phosphodiesterase 1 (20596.2 nM), and EPAC2 (8912.5 nM). Moreover, it induces synthetic lethality in tumor cells producing 2HG with potencies ranging from 10322.5 nM to 9200.0 nM and shows antiviral activity against Foot and Mouth Disease Virus (35481.3 nM). In enzymatic assays for human HDAC6, it exhibits 10.39% inhibition with a commercial peptide substrate but a negative inhibition of -2.49% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).

Chemical Properties

Molecular Weight	294.8
Formula	C₁₄H₁₅ClN₂OS
Cas No.	300851-67-6
Smiles	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1
Relative Density.	1.290 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (339.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3921 mL	16.9607 mL	33.9213 mL	169.6065 mL
5 mM	0.6784 mL	3.3921 mL	6.7843 mL	33.9213 mL
10 mM	0.3392 mL	1.6961 mL	3.3921 mL	16.9607 mL
20 mM	0.1696 mL	0.8480 mL	1.6961 mL	8.4803 mL
50 mM	0.0678 mL	0.3392 mL	0.6784 mL	3.3921 mL
100 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6961 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc