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SU5408
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Catalog No. T4026Cas No. 15966-93-5
Alias VEGFR2 Kinase Inhibitor I
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.
SU5408
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Purity: 99.35%
Catalog No. T4026Alias VEGFR2 Kinase Inhibitor ICas No. 15966-93-5
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $64 | In Stock | In Stock | |
| 5 mg | $197 | In Stock | In Stock | |
| 10 mg | $297 | In Stock | In Stock | |
| 25 mg | $546 | In Stock | In Stock | |
| 50 mg | $737 | In Stock | In Stock | |
| 100 mg | $953 | In Stock | In Stock | |
| 500 mg | $1,880 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $217 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.35%
Appearance:Solid
Color:orange
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Product Introduction
SU5408 AI Summary
SU5408 inhibits tyrosine phosphorylation of murine VEGF receptor (FLK-1 RTK) with an IC50 of 70.0 nM and shows significant inhibition of VEGFR with an IC50 of 70.0 nM. It exhibits no significant inhibition on human Platelet-derived growth factor receptor beta (PDGF RTK), human Epidermal growth factor receptor (EGF RTK), human Her-2 receptor tyrosine kinase (HER-2 RTK), and human Insulin-like growth factor I receptor at concentrations up to 100,000.0 nM. In addition, SU5408 inhibits bPDGFR in human PAC1 cells with an IC50 of 4000.0 nM. It also targets FLT3 with an IC50 of 4300.0 nM, ABL with an IC50 of 19000.0 nM, ALK with an IC50 of 5400.0 nM, and inhibits human recombinant His-tagged RET expressed in Sf9 insect cells with an IC50 of 760.0 nM. Moreover, it inhibits the growth of mouse BA/F3 cells with an IC50 of 2600.0 nM and mouse BaPTC2 cells with an IC50 of 25.0 nM. Different kinases and proteins exhibit various degrees of thermal melting changes upon binding with SU5408..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase. |
| Targets&IC50 | VEGFR2:70 nM. |
| Synonyms | VEGFR2 Kinase Inhibitor I |
| Molecular Weight | 310.35 |
| Formula | C18H18N2O3 |
| Cas No. | 15966-93-5 |
| Smiles | CCOC(=O)c1c(C)[nH]c(\C=C2\C(=O)Nc3ccccc23)c1C |
| Relative Density. | 1.271 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (16.11 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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