Anti-H3-K4-HMTase SETD7 Polyclonal Antibody is a Rabbit antibody targeting H3-K4-HMTase SETD7. Anti-H3-K4-HMTase SETD7 Polyclonal Antibody can be used in WB.

IgG

Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse)

Sample:
Lane 1: Hela (Human) Cell Lysate at 30 μg
Lane 2: U87MG (Human) Cell Lysate at 30 μg
Lane 3: U251 (Human) Cell Lysate at 30 μg
Lane 4: Huvec (Human) Cell Lysate at 30 μg
Primary: Anti-H3-K4-HMTase SETD7 (TMAB-06864) IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 47 kD

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human SETD7

Human

SETD7

Histone-lysine N-methyltransferase SETD7

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.